Basic Information

Symbol
WNT3A
RNA class
mRNA
Alias
Wnt Family Member 3A Wingless-Type MMTV Integration Site Family, Member 3A Protein Wnt-3a
Location (GRCh38)
1:228006924-228061271
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_033131.4
Sequence length
2996.0 nt
GC content
0.6682

Transcripts

ID Sequence Length GC content
NM_033131.4 NCBI
GCGCACACCCGCGCACCCGCGGCCGCAGGAGGGCCCAGCGACGCCGCCG… 2996 nt 0.6682
Summary

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that ethanol exposure during neural stem cell differentiation significantly altered the expression of key Wnt signaling pathway genes, with the WNT3A being specifically up-regulated at both the mRNA and protein levels in ethanol-treated cells compared to controls [Mandal et al. DOI:10.1007/S11033-015-3862-1].