Basic Information

Symbol
WNT5A
RNA class
mRNA
Alias
Wnt Family Member 5A HWNT5A Wingless-Type MMTV Integration Site Family, Member 5A WNT-5A Protein Protein Wnt-5a Epididymis Secretory Sperm Binding Protein
Location (GRCh38)
3:55465715-55490539
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003392.7
Sequence length
5841.0 nt
GC content
0.4164

Transcripts

ID Sequence Length GC content
NM_001256105.1 NCBI
GCUCCACUCGCCUCCGUGCUCCUCUCGCCCAUGGAAUUAAUUCUGGCUC… 5599 nt 0.3981
NM_001377271.1 NCBI
GGUGCGGUGCCGGCUGCCCCCUGUUGGCCGCCUUGAGAAGUCCAUUGGA… 5551 nt 0.3992
NM_001377272.1 NCBI
UCUCCCAGCAGGGGCCCUCGGAGGCCCCCAGAGGACCAGUUUCGCUGCG… 5636 nt 0.4035
NM_003392.7 NCBI
AACAGUUGCCUGCGCGCCCUCGCCGGACCGGCGGCUCCCUAGUUGCGCC… 5841 nt 0.4164
Summary

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Forensic Context

A study in mice demonstrated that Wnt5a, a signaling ligand expressed by fast muscle fibers, slow muscle fibers, and stroma-derived progenitor cells, acts on lipogenic brown adipocytes within brown adipose tissue, as identified through single-nucleus RNA-sequencing and cell-cell interaction analyses [Behrens et al. DOI:10.1016/j.molmet.2025.102252].