Basic Information

Symbol
WNT5B
RNA class
mRNA
Alias
Wnt Family Member 5B Wingless-Type MMTV Integration Site Family, Member 5B Protein Wnt-5b WNT-5B Protein
Location (GRCh38)
12:1529854-1647243
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_032642.3
Sequence length
2238.0 nt
GC content
0.5862

Transcripts

ID Sequence Length GC content
NM_030775.2 NCBI
UAUUCUUCCAAAUGGAAACUGCUAAUUUUUGAAGCAGAAGGUUGACAGC… 2184 nt 0.5801
NM_032642.3 NCBI
AGUCACAGCCACAGUGACCAUUAGCAGGCACCCAGGCCUGUCUUUGGCU… 2238 nt 0.5862
Summary

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that Wnt5b, a signaling ligand, is expressed by fast muscle fibers, slow muscle fibers, and stroma-derived progenitors and acts on lipogenic brown adipocytes [Behrens et al. DOI:10.1016/j.molmet.2025.102252].