Basic Information

Symbol
WRAP53
RNA class
mRNA
Alias
WD Repeat Containing Antisense To TP53 TCAB1 Telomerase Cajal Body Protein 1 WDR79 WD Repeat-Containing Protein 79 WRAP53beta FLJ10385 WD40 Repeat-Containing Protein Encoding RNA Antisense To P53 WD40 Repeat-Containing Protein Antisense To TP53 Gene WD40 Repeat-Containing Protein Antisense To TP53 WD Repeat Containing, Antisense To TP53 WD Repeat-Containing Protein WRAP53 WD-Encoding RNA Antisense To P53 WD Repeat Domain 79 WD40 Protein Wrap53 DKCB3
Location (GRCh38)
17:7686071-7703505
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001143992.2
Sequence length
1749.0 nt
GC content
0.5820

Transcripts

ID Sequence Length GC content
NM_001143990.2 NCBI
UGAAUUCGAGUUCCGCCUCCUACCAGGAAGAACCGGCUCGGGCCGGAGG… 1818 nt 0.5875
NM_001143991.2 NCBI
GCAAAGUGUCCCCGGAGCCCAGCAGCUACCUGCUCCCUGGACGGUGGCU… 1839 nt 0.5813
NM_001143992.2 NCBI
AGUGCUUUCAAAAGAAUUGGCGUCCGCUGUUCGCCUCUCCUCCCGGGAG… 1749 nt 0.5820
NM_018081.2 NCBI
GUCCCGGCUCCGCGGGUUCCGUGGGUCGCCCGCGAAAUCUGAUCCGGGA… 1982 nt 0.5817
Summary

This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]

Forensic Context

A study in humans demonstrated that the WRAP53 gene was downregulated as part of the inhibited telomere maintenance pathway in the lungs during septic shock [Pinheiro da Silva et al. DOI:10.1111/jcmm.17938]. A review of lncRNA functions noted that the WRAP53 controls induction of the tumor suppressor p53 upon DNA damage and binds CTCF [Flynn and Chang DOI:10.1016/j.stem.2014.05.014].