Basic Information

Symbol
WSB1
RNA class
mRNA
Alias
WD Repeat And SOCS Box Containing 1 SWIP1 WD Repeat And SOCS Box-Containing Protein 1 SOCS Box-Containing WD Protein SWiP-1 DKFZp564B0482 DKFZp564A122 WSB-1 WD Repeat And SOCS Box-Containing 1
Location (GRCh38)
17:27294067-27315926
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_015626.10
Sequence length
5105.0 nt
GC content
0.4159

Transcripts

ID Sequence Length GC content
NM_001348350.2 NCBI
AGUGUCUCGUUUGCAGUCGGCGCUUUAGGGGAACUGUCUUCCUCCGCAG… 4991 nt 0.4143
NM_015626.10 NCBI
AGUGUCUCGUUUGCAGUCGGCGCUUUAGGGGAACUGUCUUCCUCCGCAG… 5105 nt 0.4159
NM_134265.4 NCBI
AGUGUCUCGUUUGCAGUCGGCGCUUUAGGGGAACUGUCUUCCUCCGCAG… 4667 nt 0.4159
Summary

This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that acute alcohol exposure during neurulation induces rapid, time-dependent transcriptomic changes in the rostroventral neural tube, with WSB1 showing a dynamic expression pattern, being down-regulated at 2 hours and up-regulated at 4 hours post-exposure, a finding validated by qRT-PCR [Boschen et al. DOI:10.1016/J.Alcohol.2022.09.001].