Basic Information
Symbol
BPY2
RNA class
mRNA
Alias
Basic Charge Y-Linked 2
BPY2A
VCY2A
VCY2
Testis-Specific Basic Protein Y 2
Variably Charged Protein Y 2
Testis-Specific Basic Protein On Y, 2
Basic Protein On Y Chromosome 2
Variable Charge, Y-Linked, 2
Basic Charge, Y-Linked 2
VCY2B
VCY2C
Location (GRCh38)
Y:22973819-23005465
Forensic tag(s)
Tissue/body fluid identification
MANE select
Transcript ID
NM_004678.3
Sequence length
1206.0 nt
GC content
0.4312
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-311.40 kcal/mol
Thermodynamic ensemble
Free energy:
-335.60 kcal/mol
Frequency:
0.0000
Diversity:
294.53
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((((((((.....((.(((((...))))).)).....)))))..)))))).......(((..((((..((......(((((((((((......((((...(((((((...((((((((....((.((((((.((((((.......(((((((((.....((((((...((...))...))))))....(((.(((........)))..)))..((((.....))))))))))))).....................((((......))))...((((((......((((((.((((((((..((((.(((....))).))))..)...))))))).))))))......)))))))).)))).)))))).)).))))))))((((((......((((..((((..(((.(..(((........((((((((.........(((....))).......))))))))........)))..).)))..))))..))))...))))))......((((.(((((....(((((((....(((((((...(((((((.....(((...(((((.....((((((.((.(((((((((((..........)))))))...(((((...)))))....)))).))....))))))...((((.(((....))).))))((((...(((....(((.......)))...))))))))))))..)))...))))))))))))))..(((((((((.....))))..)))))))))))).........((......)))))))..))))..)))))))...))))(((((((((((...(((((.(((((........................))))).)))))...(((((((..((.((((..(((.....((............)).)))..))))..))..)))))))....))))))))))).(((((((.........(((((....)))))......)))))))...((((((...((((........))))......(((((((((((...((...(((((.....)))))...)).....)))))))))))..))))))((((......)))).(((((.(((((((........)))).)))))))))))..)))))))).......))..))))))).........................
Thermodynamic Ensemble Prediction
.,{(((,((((.....((.(((((...})))).)).....)))))},}|}}}|(({....(((..((((..((......{{(((({(..((((..,.....,,)))),,}},,((((((((....{{.((((((.((((((.{{({{,(((((((((.,{{((((({(,,,(({,,{|{{.||,,.,.,}}||}}}||,,....,.,}),,}}}..((((.....))))))))))))).....,,...,,......,..((((......))))...||||||......(((((({,,,,,,,...,|||}|||....,,}.,,,,..|,..,,}},,|.|}}}}),,....))))}})).)))).)))))).)}.)))))))).....((((((.....{{(.((({...((((((((((({{(((({{{(((.{{...(((((((....,|{(((((.(({{,|,....,,}}.)).)))))),||....{{((({{{{{{((({..{{{{({({.((((({...(((((((....((((({,..{(((((((.....(((...(((((.....((((((,((.(((((((((((..........)))))))...(((((...)))))....)))).)).,,.})))))...{(({.(((....})).}))}(({(...{((....(({.......))},,.))))})))))))..)))...))))))))))))))..(((({{((({....,.)))))))))))))))).........((,.....})}}})).,)}}.....,}})}}...,..(((((((((((...(((((.(((((.,,.....,{.....,}.....,,))))).)))))...(((((((..{{.((((..({{.....{{............)}.}}}..))))..}}..)))))))....)))))))))))...,,}|,,})))))}}(((((....)))))..))))))).)).}))))))))...((((........))))......{(((((,((,,...,.}}.||}}|.....))))))))))))..}))),)))....))))))..((((......)))).,((((.{{{{(((........)))).}})))))}.....,}}}}}}}....,..))..))))))).....}))}................
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| AAUAUCUCAGGACCCAGGACCAUGUGAUAUGGGCCCAACACCUGGAUGA… | 1206 nt | 0.4312 |
Summary
This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. The encoded protein interacts with ubiquitin protein ligase E3A and may be involved in male germ cell development and male infertility. Three nearly identical copies of this gene exist on chromosome Y; two copies are part of a palindromic region. This record represents the copy outside of the palidromic region. [provided by RefSeq, Jul 2008]
Forensic Context
A collaborative study in humans demonstrated that the BPY2 was evaluated in a preliminary study but gave inconsistent results during singleplex testing and was not included in the final validated semen pentaplex [Haas et al. DOI:10.1016/j.fsigen.2012.10.011].