Basic Information

Symbol
WTAP
RNA class
mRNA
Alias
WT1 Associated Protein KIAA0105 Mum2 Wilms Tumor 1-Associating Protein Wilms Tumor 1 Associated Protein Pre-MRNA-Splicing Regulator WTAP Female-Lethal(2)D Homolog MGC3925 HFL(2)D Putative Pre-MRNA Splicing Regulator Female-Lethal(2D) Wilms' Tumour 1-Associating Protein WT1-Associated Protein PNAS-132
Location (GRCh38)
6:159716432-159756319
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001270531.2
Sequence length
2105.0 nt
GC content
0.4418

Transcripts

ID Sequence Length GC content
NM_001270531.2 NCBI
CUCCCUCAGCGCCAUUUUGUGGCAGCGAGACCCACAAAUAAAGGGGAGC… 2105 nt 0.4418
NM_001270532.2 NCBI
CGCUUCCCUUACUGAGCUUGCUGAGCUCCGGGGCCCGCGGAGCUCGCGC… 1507 nt 0.4287
NM_001270533.2 NCBI
CUCCCUCAGCGCCAUUUUGUGGCAGCGAGACCCACAAAUAAAGGGGAGC… 1488 nt 0.4328
NM_004906.5 NCBI
CGCUUCCCUUACUGAGCUUGCUGAGCUCCGGGGCCCGCGGAGCUCGCGC… 2124 nt 0.4388
NM_152857.3 NCBI
CUCCCUCAGCGCCAUUUUGUGGCAGCGAGACCCACAAAUAAAGGGGAGC… 1708 nt 0.4333
NM_152858.3 NCBI
CGCUUCCCUUACUGAGCUUGCUGAGCUCCGGGGCCCGCGGAGCUCGCGC… 1727 nt 0.4296
Summary

The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in several transcript variants encoding three different isoforms. [provided by RefSeq, Jul 2012]

Forensic Context

A study in mice demonstrated that the WTAP knockdown induces G2 accumulation in human umbilical vein endothelial cells and reduces cyclin A2, while also facilitating desmoplakin mRNA m6A methylation to promote endothelial cell angiogenesis and inhibiting vascular smooth muscle cell proliferation but facilitating apoptosis [Chen et al. DOI:10.1155/2021/8813909].