Basic Information

Symbol
WWC1
RNA class
mRNA
Alias
WW And C2 Domain Containing 1 KIBRA KIAA0869 PPP1R168 Protein Phosphatase 1, Regulatory Subunit 168 WW, C2 And Coiled-Coil Domain Containing 1 Kidney And Brain Protein HBeAg-Binding Protein 3 Protein KIBRA WW Domain-Containing Protein 1 Protein WWC1 MEMRYQTL HBEBP36 HBEBP3
Location (GRCh38)
5:168291563-168472303
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_015238.3
Sequence length
7136.0 nt
GC content
0.5436

Transcripts

ID Sequence Length GC content
NM_001161661.2 NCBI
GUUUCCGGGGCAGCGCGGUUACCUGCACCGCCCGAGCCGCACCUGGCGG… 7154 nt 0.5442
NM_001161662.2 NCBI
GUUUCCGGGGCAGCGCGGUUACCUGCACCGCCCGAGCCGCACCUGGCGG… 7151 nt 0.5441
NM_015238.3 NCBI
GUUUCCGGGGCAGCGCGGUUACCUGCACCGCCCGAGCCGCACCUGGCGG… 7136 nt 0.5436
Summary

The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Forensic Context

A study in mice and human heart samples demonstrated that the WWC1 is a potential alternative upstream regulator of the Hippo pathway in the molecular pathogenesis of arrhythmogenic cardiomyopathy [Chen et al. DOI:10.1161/CIRCRESAHA.114.302810].