Basic Information

Symbol
WWP2
RNA class
mRNA
Alias
WW Domain Containing E3 Ubiquitin Protein Ligase 2 AIP2 NEDD4-Like E3 Ubiquitin-Protein Ligase WWP2 HECT-Type E3 Ubiquitin Transferase WWP2 Atrophin-1-Interacting Protein 2 Atrophin-1 Interacting Protein 2 WW Domain-Containing Protein 2 EC 2.3.2.26 WWp2-Like EC 6.3.2
Location (GRCh38)
16:69762281-69944553
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001270454.2
Sequence length
4487.0 nt
GC content
0.5737

Transcripts

ID Sequence Length GC content
NM_001270453.2 NCBI
AUUUUAUAGAAACGUUUAGUACUCACCAAGGCCCUCAGUGGAACUGGCU… 4225 nt 0.5730
NM_001270454.2 NCBI
GCGGGCGGUGGAAGGCGGAAGUAGGAGAGGAGUUCGGCGCCGCUUCUGU… 4487 nt 0.5737
NM_001270455.2 NCBI
GCGGGCGGUGGAAGGCGGAAGUAGGAGAGGAGUUCGGCGCCGCUUCUGU… 2634 nt 0.4749
NM_007014.5 NCBI
GCGGGCGGUGGAAGGCGGAAGUAGGAGAGGAGUUCGGCGCCGCUUCUGU… 4540 nt 0.5729
NM_199424.3 NCBI
AGUCGCCUUGGCCGCCUUGAGCCGGAGCUGAGCGGAGGCACUGGGCCGA… 3624 nt 0.5676
Summary

This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10. [provided by RefSeq, Jul 2012]

Forensic Context

No relevant information is available at the moment.