Basic Information

Symbol
XIAP
RNA class
mRNA
Alias
X-Linked Inhibitor Of Apoptosis BIRC4 HILP API3 X-Linked Inhibitor Of Apoptosis, E3 Ubiquitin Protein Ligase Baculoviral IAP Repeat-Containing Protein 4 RING-Type E3 Ubiquitin Transferase XIAP E3 Ubiquitin-Protein Ligase XIAP Inhibitor Of Apoptosis Protein 3 IAP-Like Protein 1 X-Linked IAP HIAP-3 ILP-1 IAP-3 HIAP3 X-Linked Inhibitor Of Apoptosis Protein Baculoviral IAP Repeat-Containing 4 IAP-Like Protein EC 2.3.2.27 ILP1 MIHA XLP2 IAP3 ILP
Location (GRCh38)
X:123859693-123913972
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001167.4
Sequence length
8558.0 nt
GC content
0.3892

Transcripts

ID Sequence Length GC content
NM_001167.4 NCBI
GAGGCCCUGACGUGGACACACUUCGGGUUUCACGACUCCGGGUUUCUCC… 8558 nt 0.3892
NM_001204401.2 NCBI
CUUACUGCCCCCAUCCGGUUCGGGGAGGUGGCGGGACCUUGGCGGCGCC… 8409 nt 0.3846
NM_001378590.1 NCBI
GCUUGCCCGGGUUCCUCGGACUGCCGACGGCAGGCGUGGGUGGGUGGGU… 8413 nt 0.3835
NM_001378591.1 NCBI
CUUACUGCCCCCAUCCGGUUCGGGGAGGUGGCGGGACCUUGGCGGCGCC… 8536 nt 0.3899
NM_001378592.1 NCBI
GAGGUGCUCACUGCGCAUGUGCGCGCGCUAGAAAAGGUGGACAAGUCCU… 8348 nt 0.3816
Summary

This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]

Forensic Context

A study in human cadaver liver tissues demonstrated that the XIAP was up-regulated greater than 28-fold in decaying tissues compared to a control, as part of the apoptotic thanatotranscriptome where pro-apoptotic genes were generally up-regulated over a 48-hour postmortem interval [Javan et al. DOI:10.1007/S12024-015-9704-6]. Research in human postmortem prostate tissues further showed that the XIAP was significantly up-regulated in a time-dependent manner, with its expression significantly elevated at longer postmortem intervals alongside other anti-apoptotic genes [Tolbert et al. DOI:10.1016/j.gene.2018.06.090].