Basic Information

Symbol
XIRP2
RNA class
mRNA
Alias
Xin Actin Binding Repeat Containing 2 CMYA3 Xin Actin-Binding Repeat-Containing Protein 2 Cardiomyopathy-Associated Protein 3 Cardiomyopathy Associated 3 Myomaxin Beta-Xin Xeplin Xin Repeat Protein 2
Location (GRCh38)
2:166888480-167259753
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_152381.6
Sequence length
12682.0 nt
GC content
0.3932

Transcripts

ID Sequence Length GC content
NM_001079810.4 NCBI
AUUAUUUGGAGAAAUCUGGCAGGUCUCUAGGCAGACAAAAGGGAACAUC… 3303 nt 0.4087
NM_001199143.2 NCBI
AUUAUUUGGAGAAAUCUGGCAGGUCUCUAGGCAGACAAAAGGGAACAUC… 3402 nt 0.4106
NM_001199144.2 NCBI
GAUAGACCCUUCAGUGGAGCGGGCCUCCACUGCACCCAUUGCUUUCAGG… 12184 nt 0.3885
NM_001199145.2 NCBI
GAUAGACCCUUCAGUGGAGCGGGCCUCCACUGCACCCAUUGCUUUCAGG… 2805 nt 0.3911
NM_152381.6 NCBI
AUUAUUUGGAGAAAUCUGGCAGGUCUCUAGGCAGACAAAAGGGAACAUC… 12682 nt 0.3932
Summary

Enables actin filament binding activity. Predicted to be involved in actin filament organization and regulation of actin filament organization. Predicted to act upstream of or within cardiac muscle tissue morphogenesis; cell-cell junction organization; and ventricular septum development. Located in focal adhesion and stress fiber. Implicated in depressive disorder. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice demonstrated that the XIRP2 is a marker for stress-responsive cardiomyocytes, being expressed in the stress-responsive ventricular cardiomyocyte cluster vCM3 and the mouse cardiomyocyte cluster CM5 following myocardial infarction [Bian et al. DOI:10.3892/mmr.2025.13680].