Basic Information

Symbol
XRCC6
RNA class
mRNA
Alias
X-Ray Repair Cross Complementing 6 X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 6 G22P1 KU70 ML8 X-Ray Repair Cross-Complementing Protein 6 Thyroid Autoantigen 70kDa (Ku Antigen) ATP-Dependent DNA Helicase 2 Subunit 1 Thyroid Autoantigen 70kD (Ku Antigen) 5'-Deoxyribose-5-Phosphate Lyase Ku70 Lupus Ku Autoantigen Protein P70 70 KDa Subunit Of Ku Antigen DNA Repair Protein XRCC6 Ku Autoantigen, 70kDa 5'-DRP Lyase Ku70 D22S731 D22S671 CTC75 CTCBF TLAA ATP-Dependent DNA Helicase II, 70 KDa Subunit ATP-Dependent DNA Helicase II 70 KDa Subunit CTC Box Binding Factor 75 KDa Subunit CTC Box-Binding Factor 75 KDa Subunit Thyroid-Lupus Autoantigen P70 Ku Autoantigen P70 Subunit Thyroid-Lupus Autoantigen EC 4.2.99.- EC 3.6.4.- Ku70
Location (GRCh38)
22:41620786-41664087
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001469.5
Sequence length
2122.0 nt
GC content
0.4840

Transcripts

ID Sequence Length GC content
NM_001288976.2 NCBI
AUGCGUGGAUUGUCGUCUUCUGUCCAAGUUGGUCGCUUCCCUGCGCCAA… 2187 nt 0.4879
NM_001288977.2 NCBI
AUGCGUGGAUUGUCGUCUUCUGUCCAAGUUGGUCGCUUCCCUGCGCCAA… 1999 nt 0.4917
NM_001288978.2 NCBI
AUGCGUGGAUUGUCGUCUUCUGUCCAAGUUGGUCGCUUCCCUGCGCCAA… 2009 nt 0.4898
NM_001469.5 NCBI
AUGCGUGGAUUGUCGUCUUCUGUCCAAGUUGGUCGCUUCCCUGCGCCAA… 2122 nt 0.4840
Summary

The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that the XRCC6 (Ku70) was significantly downregulated in oligodendrocytes in a post-mortem interval (PMI)-dependent manner, and its product is a critical anti-apoptotic protein [Guo et al. DOI:10.1016/j.ijbiomac.2025.147708].