Basic Information

Symbol
YBX3
RNA class
mRNA
Alias
Y-Box Binding Protein 3 ZONAB CSDA1 DbpA CSDA Single-Strand DNA-Binding Protein NF-GMB Cold Shock Domain-Containing Protein A Cold-Shock Domain Containing A1 Y-Box-Binding Protein 3 DNA-Binding Protein A ZO-1-Associated Nucleic Acid-Binding Protein Cold Shock Domain Protein A Cold-Shock Domain Protein A DBPA
Location (GRCh38)
12:10699077-10723388
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden death from respiratory system disease Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003651.5
Sequence length
1931.0 nt
GC content
0.5463

Transcripts

ID Sequence Length GC content
NM_001145426.2 NCBI
AGUAAGAUCGAGCGAGGAGCCCAAGAGAGAGCGCGCAGCACGAAGCUCG… 1724 nt 0.5360
NM_003651.5 NCBI
AGUAAGAUCGAGCGAGGAGCCCAAGAGAGAGCGCGCAGCACGAAGCUCG… 1931 nt 0.5463
Summary

Enables RNA binding activity. Involved in cellular hyperosmotic response; cellular response to tumor necrosis factor; and negative regulation of programmed cell death. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans demonstrated that the YBX3 mRNA is downregulated in the serum of patients with idiopathic pulmonary fibrosis (IPF) compared to healthy controls, showing excellent diagnostic performance with an AUROC of 0.944, 90% sensitivity, and 88.9% specificity, and its expression correlates with cigarette pack-years [Di Mauro et al. DOI:10.3390/Ijms21228812]. In a separate forensic investigation on human cardiac tissue, the YBX3 was identified as a potential biomarker for mechanical asphyxia, showing differential expression when compared to deaths from craniocerebral injury and hemorrhagic shock [Zeng et al. DOI:10.1007/S00414-017-1616-4].