Basic Information

Symbol
YTHDF1
RNA class
mRNA
Alias
YTH N6-Methyladenosine RNA Binding Protein F1 C20orf21 Dermatomyositis Associated With Cancer Putative Autoantigen 1 YTH N(6)-Methyladenosine RNA Binding Protein 1 YTH N6-Methyladenosine RNA Binding Protein 1 YTH Domain-Containing Family Protein 1 YTH Domain Family, Member 1 YTH Domain Family 1 FLJ20391 DACA-1 DF1 YTH Domain Family Protein 1
Location (GRCh38)
20:63195429-63216139
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_017798.4
Sequence length
3198.0 nt
GC content
0.5091

Transcripts

ID Sequence Length GC content
NM_017798.4 NCBI
GUCGCCGCCGCCGCCGCCAUUGGAGUCGACGCCUCCUCAGUGCGUCCGC… 3198 nt 0.5091
Summary

Enables N6-methyladenosine-containing RNA reader activity and ribosome binding activity. Involved in mRNA destabilization; positive regulation of translational initiation; and stress granule assembly. Located in P-body and cytoplasmic stress granule. Implicated in colorectal cancer. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice and human tissues demonstrated that the YTHDF1 binds to m6A-modified COL3A1, COL1A1, and ELN mRNAs to stabilize them, promoting pathological extracellular matrix deposition in hypertrophic scarring [Zhang et al. DOI:10.7150/ijbs.114988].