Basic Information

Symbol
YWHAB
RNA class
mRNA
Alias
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Alpha Polypeptide Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Beta Polypeptide 14-3-3 Protein Beta/Alpha 14-3-3 Alpha Protein 1054 KCIP-1 YWHAA Protein Kinase C Inhibitor Protein-1 Protein Kinase C Inhibitor Protein 1 Epididymis Secretory Protein Li 1 14-3-3 Beta HEL-S-1 GW128 HS1
Location (GRCh38)
20:44885676-44908532
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_139323.4
Sequence length
3020.0 nt
GC content
0.4225

Transcripts

ID Sequence Length GC content
NM_003404.5 NCBI
GGAAGUGGAGCUACCGCCACCGCCGCCGCCGAUUCCGGAGCCGGGGUAG… 3115 nt 0.4254
NM_139323.4 NCBI
GGAAGUGGAGCUACCGCCACCGCCGCCGCCGAUUCCGGAGCCGGGGUAG… 3020 nt 0.4225
Summary

This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans demonstrated that the YWHAB was identified as a high-confidence gene common between mice and humans within the top 10% of genes related to lifetime alcohol consumption in postmortem prefrontal cortex [Farris et al. DOI:10.1038/Mp.2014.159].