Basic Information

Symbol
ZBP1
RNA class
mRNA
Alias
Z-DNA Binding Protein 1 DLM1 DAI C20orf183 DLM-1 Tumor Stroma And Activated Macrophage Protein DLM-1 DNA-Dependent Activator Of IRFs Z-DNA-Binding Protein 1 DJ718J7.3 DNA-Dependent Activator Of IFN-Regulatory Factors Chromosome 20 Open Reading Frame 183
Location (GRCh38)
20:57603575-57620576
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_030776.3
Sequence length
2142.0 nt
GC content
0.5663

Transcripts

ID Sequence Length GC content
NM_001160417.2 NCBI
AGAGCUGCAAGAAGCACCAGGCUCGGCCACUUCAGAAGCCCCAGCCUCG… 2139 nt 0.5666
NM_001160418.2 NCBI
AGAGCUGCAAGAAGCACCAGGCUCGGCCACUUCAGAAGCCCCAGCCUCG… 1917 nt 0.5644
NM_001160419.3 NCBI
AGAGCUGCAAGAAGCACCAGGCUCGGCCACUUCAGAAGCCCCAGCCUCG… 1073 nt 0.5405
NM_001323966.2 NCBI
AGAGCUGCAAGAAGCACCAGGCUCGGCCACUUCAGAAGCCCCAGCCUCG… 848 nt 0.5295
NM_030776.3 NCBI
AGAGCUGCAAGAAGCACCAGGCUCGGCCACUUCAGAAGCCCCAGCCUCG… 2142 nt 0.5663
Summary

This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Forensic Context

A study in mice demonstrated that the ZBP1 was upregulated in the late stage of lethal infection (H06) and as bacterial load reduced in the non-lethal model, indicating its involvement in the pro-inflammatory response [Zhang et al. DOI:10.1093/jimmun/vkaf140].