Basic Information

Symbol
ZBTB20
RNA class
mRNA
Alias
Zinc Finger And BTB Domain Containing 20 DPZF Zinc Finger Protein 288 ODA-8S ZNF288 Zinc Finger And BTB Domain-Containing Protein 20 DKFZp566F123 Dendritic-Derived BTB/POZ Zinc Finger Protein Dendritic Cell-Derived BTB/POZ Zinc Finger BTB/POZ Zinc Finger Protein DPZF PRIMS HOF
Location (GRCh38)
3:114314500-115147356
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001348800.3
Sequence length
27503.0 nt
GC content
0.3943

Transcripts

ID Sequence Length GC content
NM_001348804.3 NCBI
GCAGUGUGUGUAUAUACACAACAUCAAGAGCAGGAAAAUGGACUCAUUA… 27207 nt 0.3932
NM_001348805.3 NCBI
GCAGUGUGUGUAUAUACACAACAUCAAGAGCAGGAAAAUGGACUCAUUA… 27403 nt 0.3935
NM_001393393.1 NCBI
AUUACUAAAGUCUGUUCUGAGAGCAUUUACAGCUUUCCGGAGAGUCUGA… 27192 nt 0.3939
NM_001393394.1 NCBI
AUUACUAAAGUCUGUUCUGAGAGCAUUUACAGCUUUCCGGAGAGUCUGA… 27258 nt 0.3940
NM_001393395.1 NCBI
AUUACUAAAGUCUGUUCUGAGAGCAUUUACAGCUUUCCGGAGAGUCUGA… 27074 nt 0.3931
NM_001393396.1 NCBI
AUUACUAAAGUCUGUUCUGAGAGCAUUUACAGCUUUCCGGAGAGUCUGA… 27028 nt 0.3930
NM_015642.7 NCBI
CUUCUGCCGAAGAAGUAGGGGCGGGGGGAAGUUUAGGAGUUGAGGAAAG… 27143 nt 0.3932
Showing 11 to 17 of 17 entries
Summary

This gene, which was initially designated as dendritic cell-derived BTB/POZ zinc finger (DPZF), belongs to a family of transcription factors with an N-terminal BTB/POZ domain and a C-terminal DNA-bindng zinc finger domain. The BTB/POZ domain is a hydrophobic region of approximately 120 aa which mediates association with other BTB/POZ domain-containing proteins. This gene acts as a transcriptional repressor and plays a role in many processes including neurogenesis, glucose homeostasis, and postnatal growth. Mutations in this gene have been associated with Primrose syndrome as well as the 3q13.31 microdeletion syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]

Forensic Context

A study in mice demonstrated that the ZBTB20 is a differentially expressed RNA marker involved in chromatin remodeling in type 2 alveolar cells during radiation pneumonitis [Yang et al. DOI:10.3390/antiox11081457]. In a separate investigation of acute myocardial infarction in mice, the ZBTB20 was identified as a target mRNA for multiple downregulated cardioprotective miRNAs, including miR-142a-3p, and its expression was negatively correlated with miR-142a-3p, indicating its role in post-infarction molecular regulation [Tuerxun et al. DOI:10.1007/s12013-024-01528-x].