Basic Information

Symbol
ZBTB4
RNA class
mRNA
Alias
Zinc Finger And BTB Domain Containing 4 KAISO-L1 KIAA1538 ZNF903 Zinc Finger And BTB Domain-Containing Protein 4 KAISO-Like Zinc Finger Protein 1
Location (GRCh38)
17:7459366-7484263
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Time since deposition estimation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001128833.2
Sequence length
5860.0 nt
GC content
0.5811

Transcripts

ID Sequence Length GC content
NM_001128833.2 NCBI
GAUGAUGUCAGCGGCGGCGGCGGCGGCGGCAGCGGGGCCGGGCCGGGGC… 5860 nt 0.5811
NM_020899.4 NCBI
AGAGUCGUGGGUAAACCCCCCGCUCGCUGGUUGGGCGACCUUUUGAAGU… 5930 nt 0.5715
Summary

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; nucleotide binding activity; and protein homodimerization activity. Involved in DNA damage response and negative regulation of transcription by RNA polymerase II. Located in cytosol and nuclear body. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans investigating mRNA degradation for time since deposition (TsD) estimation in semen over 0–1.5 years identified the ZBTB4 as one of several mRNA markers exhibiting temporal degradation patterns [Fanzhang Lei et al. DOI:10.1093/gpbjnl/qzag007]. In an experimental investigation using a custom MPS primer panel on human body fluids, the ZBTB4 was included in a refined primer panel and displayed expression levels comparable to an initial phase in an independent time series [Hänggi et al. DOI:10.1016/j.fsigen.2025.103415].