Basic Information

Symbol
ZBTB7B
RNA class
mRNA
Alias
Zinc Finger And BTB Domain Containing 7B ZNF857B ZBTB15 HcKrox C-Krox ThPOK ZFP67 VGAF Zinc Finger And BTB Domain-Containing Protein 7B T-Helper-Inducing POZ/Krueppel-Like Factor Krueppel-Related Zinc Finger Protein CKrox Zinc Finger And BTB Domain Containing 15 Zinc Finger Protein 67 Homolog Zinc Finger Protein Th-POK Zinc Finger Protein 857B Zinc Finger And BTB Domain-Containing Protein 15 Zinc Finger Protein 67 Homolog (Mouse) ZFP-67 Zfp-67 CKROX
Location (GRCh38)
1:155002543-155018525
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001256455.2
Sequence length
3606.0 nt
GC content
0.6301

Transcripts

ID Sequence Length GC content
NM_001252406.3 NCBI
AGCAGCGAGCGGCGAGCAACUGACCGCGGCCUUCUGACCAGGACCGGAG… 3846 nt 0.6310
NM_001256455.2 NCBI
AGCAGCGAGCGGCGAGCAACUGACCGCGGCCUUCUGACCAGGACCGGAG… 3606 nt 0.6301
NM_001377451.1 NCBI
GGAAAGCAAGCUGGAGGACAGGACCGGAGCAGGGCCCCAAGCCCCCGGG… 3826 nt 0.6302
NM_001377452.1 NCBI
GGAAAGCAAGCUGGAGGACAGGUGAGACAGCAGGACAGGACCGGAGCAG… 3682 nt 0.6266
NM_001377453.1 NCBI
GGAAAGCAAGCUGGAGGACAGGUGAGACAGCAGGACAGGACCGGAGCAG… 3603 nt 0.6289
NM_001377454.1 NCBI
GGAAAGCAAGCUGGAGGACAGGUGAGACAGCAGGACAGGACCGGAGCAG… 3743 nt 0.6300
NM_001377455.1 NCBI
GGAAAGCAAGCUGGAGGACAGGACCGGAGCAGGGCCCCAAGCCCCCGGG… 3586 nt 0.6291
Summary

This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

Forensic Context

No relevant information is available at the moment.