This gene encodes a downstream effector of bone morphogenetic protein (BMP) signalling. This protein contains a zinc finger domain and functions as a transcriptional coactivator. Variation in this gene may be associated with X-linked cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Forensic Context
The review of proteomic applications in forensic science identifies the ZCCHC12 as a protein marker showing loss post-mortem in bone, contributing to the estimation of the late post-mortem interval [Alex et al. DOI:10.1016/j.scijus.2025.101320].