Basic Information

Symbol
ZDHHC18
RNA class
mRNA
Alias
ZDHHC Palmitoyltransferase 18 Zinc Finger DHHC-Type Palmitoyltransferase 18 DHHC Domain-Containing Cysteine-Rich Protein 18 Zinc Finger DHHC Domain-Containing Protein 18 Zinc Finger DHHC-Type Containing 18 Palmitoyltransferase ZDHHC18 DKFZp667O2416 DHHC-18 Zinc Finger, DHHC Domain Containing 18 EC 2.3.1.225 EC 2.3.1 DHHC18
Location (GRCh38)
1:26826688-26857604
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_032283.3
Sequence length
5045.0 nt
GC content
0.5921

Transcripts

ID Sequence Length GC content
NM_032283.3 NCBI
AGUGAGUGAGCGAGCGAGCGCCGCGCGCGCCGCCGCUGCCACCUCCGCU… 5045 nt 0.5921
Summary

Enables protein-cysteine S-palmitoyltransferase activity. Involved in negative regulation of cGAS/STING signaling pathway; negative regulation of innate immune response; and peptidyl-L-cysteine S-palmitoylation. Located in cytosol. Is active in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in Wistar-albino rats demonstrated that the ZDHHC18 gene, identified as part of a relevant injury-response network, was down-regulated at 12 hours post-mild traumatic brain injury and subsequently up-regulated at 48 hours [Colak et al. DOI:10.1016/j.injury.2012.01.021]. In human hematopoietic stem cells from cord blood, the ZDHHC18 was identified as a target gene for miR-19b and miR-19a, which showed differential expression patterns influenced by both genetic and environmental factors in twin studies [Ajami et al. DOI:10.22074/cellj.2019.5683].