Basic Information

Symbol
ZDHHC22
RNA class
mRNA
Alias
ZDHHC Palmitoyltransferase 22 Zinc Finger DHHC-Type Palmitoyltransferase 22 C14orf59 Zinc Finger DHHC Domain-Containing Protein 22 Zinc Finger DHHC-Type Containing 22 Palmitoyltransferase ZDHHC22 DHHC-22 Zinc Finger, DHHC Domain Containing 22 Putative Palmitoyltransferase ZDHHC22 Chromosome 14 Open Reading Frame 59 EC 2.3.1.225 ZDHHC22
Location (GRCh38)
14:77131270-77143032
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl UniProt GTEx

MANE select

Transcript ID
NM_174976.2
Sequence length
3408.0 nt
GC content
0.5581

Transcripts

ID Sequence Length GC content
NM_001364172.1 NCBI
ACUCGUGCGCCCAGGGCGGGCUUGUCGGCAUGGAAAGGAUUUCGGCGCC… 3421 nt 0.5528
NM_174976.2 NCBI
CCUUACUCGCUGGCGCCCAAGUGGGAAGCCAGCAGCUGCCCGCUCCCUC… 3408 nt 0.5581
Summary

Predicted to enable protein-cysteine S-palmitoyltransferase activity. Involved in protein localization to plasma membrane and protein palmitoylation. Located in Golgi apparatus; endoplasmic reticulum; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice demonstrated that the ZDHHC22 was one of the most significantly downregulated mRNA genes in lung tissue following whole-body irradiation across doses, as identified by microarray analysis [Aryankalayil et al. DOI:10.1080/09553002.2023.2214205].