Basic Information

Symbol
ZEB2
RNA class
mRNA
Alias
Zinc Finger E-Box Binding Homeobox 2 SIP1 KIAA0569 ZFHX1B SIP-1 Zinc Finger E-Box-Binding Homeobox 2 SMAD Interacting Protein 1 Smad-Interacting Protein 1 Zinc Finger Homeobox 1b SMADIP1 Zinc Finger Homeobox Protein 1b HSPC082 ZFX1B
Location (GRCh38)
2:144364364-144521057
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_014795.4
Sequence length
9265.0 nt
GC content
0.3895

Transcripts

ID Sequence Length GC content
NM_001171653.2 NCBI
AGUUCUAACCUGCUCUGCAGGAAUAACGGUCCUGCCUCCCGACACUCUU… 9193 nt 0.3890
NM_014795.4 NCBI
AGUUCUAACCUGCUCUGCAGGAAUAACGGUCCUGCCUCCCGACACUCUU… 9265 nt 0.3895
Summary

The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010]

Forensic Context

A study in mice demonstrated that the ZEB2 is upregulated in stressed cardiomyocytes, where it induces cardioprotective cross-talk between cardiomyocytes and endothelial cells and enhances post-ischemic angiogenesis [Li et al. DOI:10.3389/fcvm.2022.768834]. Further research in mouse models confirmed that the ZEB2 functions as a mediator of cardiomyocyte-endothelial cell interaction, inducing cardiomyocytes to produce TMSB4 and PTMA, which drive endothelial cell migration and proliferation [Bian et al. DOI:10.3892/mmr.2025.13680].