Basic Information

Symbol
ZFAT
RNA class
mRNA
Alias
Zinc Finger And AT-Hook Domain Containing Zinc Finger Protein 406 KIAA1485 ZNF406 ZFAT1 Zinc Finger Protein ZFAT Zinc Finger Gene In Autoimmune Thyroid Disease Zinc-Finger Gene In AITD Susceptibility Region Zinc Finger Gene In AITD Susceptibility Region Zinc Finger And AT Hook Domain Containing AITD3
Location (GRCh38)
8:134477788-134713127
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_020863.4
Sequence length
4594.0 nt
GC content
0.5424

Transcripts

ID Sequence Length GC content
NM_001029939.4 NCBI
AGUGCAGGAGUCUGAGAAGAAAGGGUGUAGAUGGAGAGGCGGUGGCCUC… 4691 nt 0.5430
NM_001167583.3 NCBI
AGUGCAGGAGUCUGAGAAGAAAGGGUGUAGAUGGAGAGGCGGUGGCCUC… 4532 nt 0.5417
NM_001174157.2 NCBI
AUCCGCCAUGUUGGAUGCCGCAGAUUCGCCAUAACCUCGCCGGCUCUUU… 4408 nt 0.5461
NM_001174158.2 NCBI
AGUGCAGGAGUCUGAGAAGAAAGGGUGUAGAUGGAGAGGCGGUGGCCUC… 4274 nt 0.5372
NM_001289394.2 NCBI
AUCCGCCAUGUUGGAUGCCGCAGAUUCGCCAUAACCUCGCCGGCUCUUU… 4753 nt 0.5437
NM_020863.4 NCBI
AUCCGCCAUGUUGGAUGCCGCAGAUUCGCCAUAACCUCGCCGGCUCUUU… 4594 nt 0.5424
Summary

This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]

Forensic Context

A study in humans demonstrated that the ZFAT was identified as a high-confidence gene in common between mice and humans within the top 10% of genes related to lifetime alcohol consumption [Farris et al. DOI:10.1038/Mp.2014.159].