Basic Information

Symbol
ZFP36L1
RNA class
mRNA
Alias
ZFP36 Ring Finger Protein Like 1 RNF162B TIS11B ERF1 Berg36 CMG1 BRF1 Zinc Finger Protein, C3H Type, 36-Like 1 Zinc Finger Protein 36, C3H1 Type-Like 1 Zinc Finger Protein 36, C3H Type-Like 1 MRNA Decay Activator Protein ZFP36L1 Butyrate Response Factor 1 TPA-Induced Sequence 11b EGF-Response Factor 1 ZFP36-Like 1 ERF-1 Early Response Factor Berg36 BERG36
Location (GRCh38)
14:68787655-68796253
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004926.4
Sequence length
3017.0 nt
GC content
0.4932

Transcripts

ID Sequence Length GC content
NM_001244698.2 NCBI
GCUCUGCGCCCGCGCGGCCCCGGAGAGGGGGCGCCUGAAGCGCCGGGUA… 2649 nt 0.4870
NM_001244701.1 NCBI
CCCCUUGCACAAAACCGAACAUCCCACCCCACCACCACCUCCAAGCUAA… 3212 nt 0.5009
NM_004926.4 NCBI
GGAGUCAGAAAGGCGAGGGGCGCCGGGAACUGGCGUGUGGGACUCCAGA… 3017 nt 0.4932
Summary

This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] CIViC Summary for ZFP36L1 Gene

Forensic Context

A study in humans identified a molecular signature of chronic cocaine abuse in postmortem midbrain dopamine neurons, where the ZFP36L1 transcript was upregulated 1.4-fold and was diagnostic for assigning subjects to the cocaine-abusing cohort with significant accuracy [Bannon et al. DOI:10.1038/Npp.2014.70].