Basic Information

Symbol
ZFYVE1
RNA class
mRNA
Alias
Zinc Finger FYVE-Type Containing 1 DFCP1 TAFF1 KIAA1589 PPP1R172 ZNFN2A1 Protein Phosphatase 1, Regulatory Subunit 172 Zinc Finger FYVE Domain-Containing Protein 1 Zinc Finger, FYVE Domain Containing 1 Double FYVE-Containing Protein 1 SR3 Zinc Finger Protein, Subfamily 2A (FYVE Domain Containing), 1 Zinc Finger Protein, Subfamily 2A, Member 1 Phosphoinositide-Binding Protein SR3 Tandem FYVE Fingers-1 Protein Tandem FYVE Fingers-1
Location (GRCh38)
14:72969451-73027131
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_021260.4
Sequence length
4380.0 nt
GC content
0.5292

Transcripts

ID Sequence Length GC content
NM_001281734.2 NCBI
ACUCCGAUCAGCUGAUCCCAACUGACAACAGGAGAGGAGGAAGCCCGGG… 4338 nt 0.5297
NM_001281735.1 NCBI
CCUUUCUCUUCUAGCUUUGGGAUCUCAGGAGGAGGAGAACCCAAGAAAC… 2641 nt 0.5399
NM_021260.4 NCBI
ACUCCGAUCAGCUGAUCCCAACUGACAACAGGAGAGGAGGAAGCCCGGG… 4380 nt 0.5292
NM_178441.2 NCBI
CCUUUCUCUUCUAGCUUUGGGAUCUCAGGAGGAGGAGAACCCAAGAAAC… 2646 nt 0.5401
Summary

The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulates the ZFYVE1 in microglia, which is involved in the autophagy pathway [Oladapo et al. DOI:10.3390/Ijms26020649].