Basic Information

Symbol
ZMAT3
RNA class
mRNA
Alias
Zinc Finger Matrin-Type 3 PAG608 WIG1 WIG-1 Zinc Finger Matrin-Type Protein 3 P53-Activated Gene 608 Protein MGC10613 FLJ12296 P53 Target Zinc Finger Protein Zinc Finger Protein WIG-1 Zinc Finger Protein WIG1 WIG-1/PAG608 Protein
Location (GRCh38)
3:178960121-179072323
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_022470.4
Sequence length
8936.0 nt
GC content
0.3818

Transcripts

ID Sequence Length GC content
NM_001375824.1 NCBI
AGUCACUUCCUGCAGCUGUUUCCCUGUGGGUCGGGUUGGACUGACUUUU… 9204 nt 0.3882
NM_001375825.1 NCBI
GGGGAGGCAGGAGACAUUAUGGAUAAAGAUUGAAGAGGGAGAGGAACAU… 9040 nt 0.3743
NM_001375826.1 NCBI
AGUCACUUCCUGCAGCUGUUUCCCUGUGGGUCGGGUUGGACUGACUUUU… 8933 nt 0.3817
NM_001375827.1 NCBI
ACUCAGUGUUAACAUUGAAGAUGUCCAGGUUGGUUAUGAAGGAUGUGAC… 8812 nt 0.3741
NM_001375828.1 NCBI
ACUCAGUGUUAACAUUGAAGAUGUCCAGGUUGGUUAUGAAGGAUGUGAC… 8933 nt 0.3775
NM_001375829.1 NCBI
AGUCACUUCCUGCAGCUGUUUCCCUGUGGGUCGGGUUGGACUGACUUUU… 9201 nt 0.3881
NM_022470.4 NCBI
AGUCACUUCCUGCAGCUGUUUCCCUGUGGGUCGGGUUGGACUGACUUUU… 8936 nt 0.3818
NM_152240.3 NCBI
AGUCACUUCCUGCAGCUGUUUCCCUGUGGGUCGGGUUGGACUGACUUUU… 9054 nt 0.3849
Summary

This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. [provided by RefSeq, Jul 2008]

Forensic Context

A study in rats demonstrated that asarum administration induced hepatotoxicity, with transcriptomic analysis revealing upregulation of the ZMAT3 alongside other p53 signaling-associated genes such as SESN1 and CDKN1A, which were integrated with metabolomic changes in a network primarily associated with bile acid biosynthesis and amino acid metabolism [Cao et al. DOI:10.3892/Etm.2020.8811].