Basic Information

Symbol
ZNF281
RNA class
mRNA
Alias
Zinc Finger Protein 281 ZBP-99 GC-Box-Binding Zinc Finger Protein 1 Zinc Finger DNA-Binding Protein 99 Transcription Factor ZBP-99 ZBP99 GZP1 ZNP-99 Transcription Factor ZNP-99
Location (GRCh38)
1:200404940-200410056
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001281293.2
Sequence length
4864.0 nt
GC content
0.4174

Transcripts

ID Sequence Length GC content
NM_001281293.2 NCBI
AGUACACGGGAGGCUUUUAAUUCCAUUGUGGAGAGGACGGCGUUAUUUU… 4864 nt 0.4174
NM_001281294.2 NCBI
AGUACACGGGAGGCUUUUAAUUCCAUUGUGGAGAGGACGGCGUUAUUUU… 4756 nt 0.4119
NM_012482.5 NCBI
AGUACACGGGAGGCUUUUAAUUCCAUUGUGGAGAGGACGGCGUUAUUUU… 4860 nt 0.4171
Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; and positive regulation of DNA-templated transcription. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice demonstrated that the ZNF281 was upregulated in common in spleen leukocytes across all three injury models of trauma/hemorrhage, burn, and LPS infusion at a 2-hour post-injury time point, as part of a large-scale microarray analysis identifying a common early transcriptional response to systemic inflammation [Brownstein et al. DOI:10.1152/physiolgenomics.00213.2005].