Basic Information

Symbol
ZNF331
RNA class
mRNA
Alias
Zinc Finger Protein 331 ZNF463 ZNF361 RITA C2H2-Like Zinc Finger Protein Rearranged In Thyroid Adenomas Zinc Finger Protein 361 Zinc Finger Protein 463 Rearranged In Thyroid Adenomas KRAB Zinc Finger Protein
Location (GRCh38)
19:53519527-53580271
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001079906.2
Sequence length
4065.0 nt
GC content
0.4386

Transcripts

ID Sequence Length GC content
NM_001079906.2 NCBI
GCACUUGCGUGGGAGUACGAGGCUGACGCGGCGGCCCUGUCCCCGUAAC… 4065 nt 0.4386
NM_001079907.1 NCBI
GCUGAGAUGGGUGAUCGGGCCUUCUGGGUGACGCAGGUGUGUGUGACAA… 4171 nt 0.4363
NM_001253798.2 NCBI
GCACUUGCGUGGGAGUACGAGGCUGACGCGGCGGCCCUGUCCCCGUAAC… 4290 nt 0.4494
NM_001253799.2 NCBI
GCACUUGCGUGGGAGUACGAGGCUGACGCGGCGGCCCUGUCCCCGUAAC… 4260 nt 0.4491
NM_001253800.3 NCBI
GCACUUGCGUGGGAGUACGAGGCUGACGCGGCGGCCCUGUCCCCGUAAC… 4279 nt 0.4459
NM_001253801.2 NCBI
AUGCGCGCUGGCCUCCAUGGGUGGCGGGACCGACUGUGUGACGCACUUG… 4059 nt 0.4375
NM_001317113.2 NCBI
GCACUUGCGUGGGAGUACGAGGCUGACGCGGCGGCCCUGUCCCCGUAAC… 4001 nt 0.4379
NM_001317114.2 NCBI
ACAUUGUUUACAAUGCAGCAAGCAAGGGACACCGAAUAGCAGCUCCGGC… 4362 nt 0.4516
NM_001317115.2 NCBI
GCACUUGCGUGGGAGUACGAGGCUGACGCGGCGGCCCUGUCCCCGUAAC… 4095 nt 0.4391
NM_001317116.2 NCBI
GGGGCGACGGAACCCGCACCUGUGAACCUCGGCAGUGCGUCCCCGGGAC… 3908 nt 0.4314
Showing 1 to 10 of 16 entries
Summary

This gene encodes a zinc finger protein containing a KRAB (Kruppel-associated box) domain found in transcriptional repressors. This gene may be methylated and silenced in cancer cells. This gene is located within a differentially methylated region (DMR) and shows allele-specific expression in placenta. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding the same protein. [provided by RefSeq, Nov 2015]

Forensic Context

A study in human neonates with hypoxic-ischemic encephalopathy (HIE) identified the ZNF331 as one of 11 significant genes in common between high-income and South Asian cohorts associated with adverse outcome, where it was downregulated in the high-income cohort but upregulated in the South Asian cohort in neonates with adverse outcome [Montaldo et al. DOI:10.1001/jamanetworkopen.2023.54433].