Basic Information

Symbol
ZNF331
RNA class
mRNA
Alias
Zinc Finger Protein 331 ZNF463 ZNF361 RITA C2H2-Like Zinc Finger Protein Rearranged In Thyroid Adenomas Zinc Finger Protein 361 Zinc Finger Protein 463 Rearranged In Thyroid Adenomas KRAB Zinc Finger Protein
Location (GRCh38)
19:53519527-53580271
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001079906.2
Sequence length
4065.0 nt
GC content
0.4386

Transcripts

ID Sequence Length GC content
NM_001317117.1 NCBI
AUGCGCGCUGGCCUCCAUGGGUGGCGGGACCGACUGUGUGACGCACUUG… 4091 nt 0.4378
NM_001317118.1 NCBI
GUCAUUGGGGGUGAUGGGGGCCGUGCUCGGUGCGCUUCUGCACCGGUGA… 4172 nt 0.4420
NM_001317119.1 NCBI
GCUGAGAUGGGUGAUCGGGCCUUCUGGGUGACGCAGGUGUGUGUGACAA… 4141 nt 0.4359
NM_001317120.2 NCBI
AGAGGGCCUUGGGGCACAGUCCAAUGAGGAGCGAGCCGGGUGGCCGGCU… 5014 nt 0.4621
NM_001317121.1 NCBI
GGUGAUCGGGCCUUCUGGGUGACGCAGGUGUGUGUGACAGCACAACCUG… 4045 nt 0.4324
NM_018555.6 NCBI
AGAGGGCCUUGGGGCACAGUCCAAUGAGGAGCGAGCCGGGUGGCCGGCU… 5052 nt 0.4618
Showing 11 to 16 of 16 entries
Summary

This gene encodes a zinc finger protein containing a KRAB (Kruppel-associated box) domain found in transcriptional repressors. This gene may be methylated and silenced in cancer cells. This gene is located within a differentially methylated region (DMR) and shows allele-specific expression in placenta. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding the same protein. [provided by RefSeq, Nov 2015]

Forensic Context

A study in human neonates with hypoxic-ischemic encephalopathy (HIE) identified the ZNF331 as one of 11 significant genes in common between high-income and South Asian cohorts associated with adverse outcome, where it was downregulated in the high-income cohort but upregulated in the South Asian cohort in neonates with adverse outcome [Montaldo et al. DOI:10.1001/jamanetworkopen.2023.54433].