Basic Information

Symbol
ZNF74
RNA class
mRNA
Alias
Zinc Finger Protein 74 ZNF520 Zfp520 Cos52 Zinc Finger Protein 520 HZNF7 Zinc Finger Protein 74 (Cos52)
Location (GRCh38)
22:20394115-20408461
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003426.4
Sequence length
3900.0 nt
GC content
0.5856

Transcripts

ID Sequence Length GC content
NM_001256523.2 NCBI
GCAGCGGCCGCCUGCUGCUCUUUGUGGCAGUCGCAGUCCUUUUGUGGGA… 3814 nt 0.5870
NM_001256524.2 NCBI
GCAGCGGCCGCCUGCUGCUCUUUGUGGCAGUCGCAGUCCUUUUGUGGGA… 3672 nt 0.5763
NM_001256525.2 NCBI
GCAGCGGCCGCCUGCUGCUCUUUGUGGCAGUCGCAGUCCUUUUGUGGGA… 3572 nt 0.5731
NM_003426.4 NCBI
GCAGCGGCCGCCUGCUGCUCUUUGUGGCAGUCGCAGUCCUUUUGUGGGA… 3900 nt 0.5856
Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in actin cytoskeleton and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in human postmortem prefrontal cortex identified a red gene module whose expression was negatively correlated with total, negative, and general psychopathology symptom scores in schizophrenia, and this module overlapped with the opioid signaling pathway and was indicated to be regulated by CREB [Miyahara et al. DOI:10.1038/S41398-023-02449-8].