Basic Information

Symbol
ZNF879
RNA class
mRNA
Alias
Zinc Finger Protein 879 DKFZp686E2433
Location (GRCh38)
5:179023804-179035064
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl UniProt GTEx

MANE select

Transcript ID
NM_001136116.3
Sequence length
3252.0 nt
GC content
0.4164

Transcripts

ID Sequence Length GC content
NM_001136116.3 NCBI
GCAGUUGCGCCCGGCAGCGACGGGAAACGUCUCUGAAUUAGGUGUUCCG… 3252 nt 0.4164
NM_001353372.2 NCBI
GCAGUUGCGCCCGGCAGCGACGGGAAACGUCUCUGAAUUAGGUGUUCCG… 3265 nt 0.4175
NM_001353373.2 NCBI
GCAGUUGCGCCCGGCAGCGACGGGAAACGUCUCUGAAUUAGGUGUUCCG… 4223 nt 0.4447
NM_001353374.2 NCBI
GCAGUUGCGCCCGGCAGCGACGGGAAACGUCUCUGAAUUAGGUGUUCCG… 4317 nt 0.4461
Summary

This gene encodes a kruppel-associated box-containing zinc finger protein (KRAB-ZFP). The encoded protein contains an N-terminal kruppel-associated box (KRAB) domain and thirteen C-terminal C2H2-type zinc finger domains. The KRAB-ZFPs represent the largest family of mammalian transcriptional repressors, which function through the recruitment of the nuclear co-factor KRAB-Associated Protein 1 (KAP1), to engage histone modifiers and induce heterochromatin formation. [provided by RefSeq, Jul 2017]

Forensic Context

A study in human patients identified the ZNF879 as a differentially expressed mRNA that is downregulated in heart failure compared to myocardial fibrosis [Wang et al. DOI:10.3389/fcvm.2021.664044].