Basic Information

Symbol
ZNHIT6
RNA class
mRNA
Alias
Zinc Finger HIT-Type Containing 6 BCD1 NY-BR-75 C1orf181 Serologically Defined Breast Cancer Antigen NY-BR-75 Zinc Finger HIT Domain-Containing Protein 6 Box C/D SnoRNA Protein 1 Zinc Finger, HIT Type 6 FLJ20729 Box C/D SnoRNA Essential 1 Homolog (S. Cerevisiae) Chromosome 1 Open Reading Frame 181 Box C/D SnoRNA Essential 1 Homolog
Location (GRCh38)
1:85649417-85708433
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_017953.4
Sequence length
6203.0 nt
GC content
0.3816

Transcripts

ID Sequence Length GC content
NM_001170670.2 NCBI
AGUCGCGUCAAGCAGGCUAUUCCGGGUUUGUGGCUGCUUGGCUCCACAC… 6086 nt 0.3784
NM_017953.4 NCBI
AGUCGCGUCAAGCAGGCUAUUCCGGGUUUGUGGCUGCUUGGCUCCACAC… 6203 nt 0.3816
Summary

Enables ATPase binding activity; TFIID-class transcription factor complex binding activity; and identical protein binding activity. Involved in box C/D snoRNP assembly; protein complex oligomerization; and snoRNA localization. Located in extracellular exosome. Part of pre-snoRNP complex. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in rats demonstrated that the ZNHIT6 is a protein-coding gene transcript whose expression is negatively correlated with alcohol consumption and positively correlated with Lrap expression, and its sum of isoforms was significantly decreased in the brains of Lrap knockout rats, which exhibited increased alcohol consumption [Saba et al. DOI:10.1111/Gbb.12698].