Basic Information

Symbol
ZSWIM8
RNA class
mRNA
Alias
Zinc Finger SWIM-Type Containing 8 KIAA0913 Zinc Finger SWIM Domain-Containing Protein 8 4832404P21Rik Pelado Dorado
Location (GRCh38)
10:73785606-73801797
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001367799.1
Sequence length
6052.0 nt
GC content
0.6059

Transcripts

ID Sequence Length GC content
NM_001242487.2 NCBI
AGCCGCCUAGAGGCCCCAGCCGCCGAGCGCUUCGUCCCGGCCCUAAGUC… 6061 nt 0.6062
NM_001242488.2 NCBI
AGCCGCCUAGAGGCCCCAGCCGCCGAGCGCUUCGUCCCGGCCCUAAGUC… 5969 nt 0.6060
NM_001367799.1 NCBI
AGCCGCCUAGAGGCCCCAGCCGCCGAGCGCUUCGUCCCGGCCCUAAGUC… 6052 nt 0.6059
NM_015037.4 NCBI
AGCCGCCUAGAGGCCCCAGCCGCCGAGCGCUUCGUCCCGGCCCUAAGUC… 6076 nt 0.6060
Summary

Enables ubiquitin-like ligase-substrate adaptor activity. Involved in positive regulation of macromolecule metabolic process; protein ubiquitination; and proteolysis involved in protein catabolic process. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice demonstrated that ZSWIM8 is a central factor in target-directed miRNA degradation (TDMD), where it binds Argonaute proteins engaged with highly complementary targets and recruits an E3 ubiquitin ligase complex to tag Ago2 for proteasomal degradation, leading to miRNA turnover [Shang et al. DOI:10.1038/s41576-023-00611-y].