Basic Information

Symbol
ZWINT
RNA class
mRNA
Alias
ZW10 Interacting Kinetochore Protein KNTC2AP Zwint1 SIP30 Outer Kinetochore KNL1 Complex Subunit ZWINT SNAP25 Interacting Protein Of 30 KDa ZW10 Interactor Zwint-1 ZW10 Interactor, Kinetochore Protein Human ZW10 Interacting Protein-1 ZW10-Interacting Protein 1 HZwint-1
Location (GRCh38)
10:56356736-56361392
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_007057.4
Sequence length
1857.0 nt
GC content
0.4523

Transcripts

ID Sequence Length GC content
NM_001005413.1 NCBI
GAUUGUGGGAAGGCAGCUGAACUCGGCGCCUGGAAAGAUGGAGGCAGCG… 1546 nt 0.4657
NM_007057.4 NCBI
AGCUGAACUCGGCGCCUGGAAAGAUGGAGGCAGCGGAGACAGAGGCGGA… 1857 nt 0.4523
NM_032997.3 NCBI
AGCUGAACUCGGCGCCUGGAAAGAUGGAGGCAGCGGAGACAGAGGCGGA… 1830 nt 0.4874
Summary

This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Forensic Context

A study in Sprague Dawley rats demonstrated that adolescent morphine exposure in females produced transgenerational attenuation of morphine self-administration and relapse-like behavior in offspring (F1) and grandoffspring (F2) [Fair M. Vassoler et al. DOI:10.1016/j.neuropharm.2016.10.006]. A study in Sprague Dawley rats demonstrated that adolescent morphine exposure in females produced transgenerational effects on gene expression in the nucleus accumbens of offspring, where the ZWINT was downregulated in Mor-F1 females compared to saline controls [Vassoler et al. DOI:10.1016/j.neuropharm.2016.10.006].