The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle. [provided by RefSeq, Jul 2008] CIViC Summary for BTG2 Gene
Forensic Context
A study in mice demonstrated that the BTG2 mRNA levels were significantly higher in ante-mortem contused skin compared to control and postmortem-injured skin, with increased levels detectable until 48 hours after death [Dong et al. DOI:10.1016/j.forsciint.2019.109937]. A study in domestic swine demonstrated that the BTG2 gene, associated with arrhythmia, exhibited further repression at the mature mRNA level compared to its nascent transcript signal following myocardial infarction, as validated by quantitative polymerase chain reaction [Kaikkonen et al. DOI:10.1161/CIRCGENETICS.117.001702].