This gene encodes a member of the acyl-CoA thioesterase protein family, and is one of four acyl-CoA hydrolase genes located in a cluster on chromosome 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Forensic Context
A study in mice demonstrated that the ACOT2 gene was down-regulated specifically by endothelial cell-specific exposure to α-particles in liver tissue [Roudkenar et al. DOI:10.1269/jrr.07078].