Basic Information

Symbol
C1QB
RNA class
mRNA
Alias
Complement C1q B Chain Complement Component 1, Q Subcomponent, Beta Polypeptide Complement Component 1, Q Subcomponent, B Chain Complement C1q Subcomponent Subunit B Complement C1q Chain B Complement Subcomponent C1q Chain B Complement Component C1q, B Chain C1QD2
Location (GRCh38)
1:22652713-22661637
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Mechanical injury analysis Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001378156.1
Sequence length
1098.0 nt
GC content
0.5829

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-430.70 kcal/mol
Thermodynamic ensemble
Free energy: -447.73 kcal/mol
Frequency: 0.0000
Diversity: 269.39
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
....((((...((.(((((...((((((..((...)).)))))).....)))))..)).(((((....)))))((((..((((......)).)).)))).....(((((((((((........))))))))))).....((((((((..............))))))))((((((.(((.((((((.(((((((....)))).((((...((((((((((...(((((((.....)))))....))...))))))))))...)).))((((((((.((.(((((((((((((((((.((((((...((..(.(((((((..((((((....))))))..))).(((...((((((.(((.(((((((.((((((((...)).))))))))))))).))).)))...(((....(((((((.(((((.(.((....)).).))).))...)))))))....)))...............(((((........)))))..)))..))).))))..)..))...)))))).(((((.......))))).((((.(((((((.....))).))))..)).))..))))))))................))))))))).))(((((((((.((((((...))))))(((((((((((.(((((((((((((....)))))))))).............)))))))).))))))...(((((((....(((.......)))(((((((((.....)))))))))..))))))).......((((....))))...(((((((((.....))))))))).)))))))))))))))))......))).))))))....((((((((((.............(((.......)))))))..))))))...........(((((..((((((................))))))..)))))..))).))))))((((.((((......)))))))).))))..((((((..(((........)).)..)))))).(((..((((((.......)))))))))(((...((..(((((.(((......))))))))...))...)))..
Thermodynamic Ensemble Prediction
....(((,,,.({,((((({..((((((..({...)).))))))...,.))))}..}}.(((((....)))))|{{{,,({({|...,,}|,|,.,,)},.{,.(((((((((((........))))))))))),,...((((((((....{......,..))))))))((((((.((((((((((((((((((.((((((...(((...((((((((((...(((((((.....)))))....))...))))))))))...,,.......}}}...)))))).)))))))......{(((((((((((,{,{,,(((({,({{.(((,{((((((....))))))}.....(((.(((.(((((((.((((((({...}).))))))))))))).))).))),,.{((,,..{{(((((.(((((.(.({....}},,.))).}}...))))))).,,{}}}...,||..........(((((((((.(((((({{(,.((({({(({{.{.{{{({((........{{{|{.......}}}}).|,..}|}.}}))},,}}..(((((.(((((((((((((.................((((((((.{{{...,)))..))).))))).......,}.)}))))))).(((((((((((((((....)))))))))).,,))))......)))))).)))))......,)))))..)))))}}....,,)).)))))))))....)))))))}|..||},.}}..,..)))))))))}.{||{{{.(({((((((.....)))))),.,,|{({{|||,,,||,,||||,,..})))}})},},,,,(((((({(((.............(((.......))))))}..))))))...........,,,|,..}|.}||}}}.....,{,.....))}))))}))))}..,)).))))))((((.((((......)))))))),||||,.{{{{{{.,|||,,......}},},,))))}}{(((..((((((.......)))))))))|((...,{..(((((.(((......))))))))...,}...)),..

Transcripts

ID Sequence Length GC content
NM_000491.5 NCBI
AGUAGGCUCUCGGCUCCUGGUCCCACUGCUGCUCAGCCCAGUGGCCUCA… 1098 nt 0.5829
NM_001371184.3 NCBI
AGUAGGCUCUCGGCUCCUGGUCCCACUGCUGCUCAGCCCAGUGGCCUCA… 1251 nt 0.5771
NM_001378156.1 NCBI
AGUAGGCUCUCGGCUCCUGGUCCCACUGCUGCUCAGCCCAGUGGCCUCA… 1098 nt 0.5829
Summary

This gene encodes the B-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum complement system. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. [provided by RefSeq, Dec 2016]

Forensic Context

A study in mice demonstrated that the C1QB is highly expressed in pro-inflammatory and repair macrophage clusters, specifically within the M1 and M2 macrophage populations following myocardial infarction [Bian et al. DOI:10.3892/mmr.2025.13680]. In human skin wound healing, the C1QB was identified as a marker for the Mac2 macrophage subtype and was involved in macrophage-fibroblast interactions [Liu et al. DOI:10.1016/j.stem.2024.11.013]. A study in mice demonstrated that the C1QB was up-regulated at 3 days post-injury specifically in skeletal muscle following a local hind limb burn, but not after a distant dorsum burn, indicating a localized immuno-inflammatory gene expression response to direct trauma [Padfield et al. DOI:10.01.ta.0000230567.56797.6c].