The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for childhood absence epilepsy. [provided by RefSeq, Dec 2010]
Forensic Context
A study in mice demonstrated that the CACNG3 was upregulated 2.31-fold in injured dorsal root ganglia following spinal nerve ligation, indicating its significant differential expression in a neuropathic pain model [Wu et al. DOI:10.1177/1744806916629048].