Basic Information

Symbol
CALCA
RNA class
mRNA
Alias
Calcitonin Related Polypeptide Alpha CGRP-Alpha Calcitonin CALC1 CGRP Calcitonin Gene-Related Peptide 1 Calcitonin Gene-Related Peptide I Alpha-Type CGRP Calcitonin 1 CGRP-I CGRP1 Calcitonin/Calcitonin-Related Polypeptide, Alpha Katacalcin PCT CT KC
Location (GRCh38)
11:14966622-14972354
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt UniProt GTEx

MANE select

Transcript ID
NM_001741.3
Sequence length
840.0 nt
GC content
0.5524

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-302.50 kcal/mol
Thermodynamic ensemble
Free energy: -317.69 kcal/mol
Frequency: 0.0000
Diversity: 140.27
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((((((....((((((((.((((((((((.(((((((.....((((((((((((((.((.((....)).)).(((..(.(((((...(((.(.((((((.(....).)))))).).)))(((((........((((..(((.((((((.(((((((..(((((((((..(((((((((.(((((((.((((.(((.....)))))))..))))).)).))(((((((....(((..((((..((....))..)))).)))..))))))))))).)))..))))))))).))))...))).)))))).)))..))))..))))).)))).).)..)))))))))).)))..)))).......))))))))))).........))))))...)))))))).......(((((((.....................((((((.......))))))..(((((....((((.((((.((((.(((....((((..(((.......)))))))...)))(((.((((........)))).)))........)))))))).)))).......((....((((((.............))))))...))...........(((((((((((((((((..((..((((((((((((.((.(((..(((..((((((...((((......))))...)))).))...))).(((((..((......)))))))........))).))...))))))))))..))..)))))))))).))))))))))))))...)))))))))))))............((((.((((...........)))).))))
Thermodynamic Ensemble Prediction
,((((,,....{(((((((.((((((((((((((((((.....(((((({(((((((.((,((.,,.}}.)).||{..{.{((((..,(({.(.((((((.(....).)))))).}.}}|(({{{,....,,.((((..(((.((((((.(((((((..(((((((((..(((((((((.(((((((.((((.(((.....)))))))..))))).)).))(((((((....(((..((((..((....))..)))).)))..))))))))))).)))..))))))))).))))...))).)))))).)))..))))..)))}).,})).}.)..)))))))))).)),.,)))).......))))))))))),.....,,.))))))...)))))))}.......(((((((........,........,,,.((((((.......))))))..(((({....((((.(,(((((((..,,({{{{,,,..|||},,{,{.,,.,,,,.}})..(((.((((........)))).)))........)))))))},)))).......{{..,.((((((.............)))))).}.))...|}.....{(((((((((((((((((..((..{{((((((((((.((.(((..(((..((((((...((((.....,)))}...)))).))...))).(((({.{{.......}))))))........))).))...))))))))))..})..)))))))))).))))))))))}}}}...))))))).,,)),.,}}.}}}},..{(((.((((.,,.....,,.)))).))),

Transcripts

ID Sequence Length GC content
NM_001033952.3 NCBI
AUCAGAGACACUGCCCAGCCCAAGUGUCGCCGCCGCUUCCACAGGGCUC… 864 nt 0.5556
NM_001033953.3 NCBI
AUCAGAGACACUGCCCAGCCCAAGUGUCGCCGCCGCUUCCACAGGGCUC… 982 nt 0.5132
NM_001378949.1 NCBI
AUCAGAGACACUGCCCAGCCCAAGUGUCGCCGCCGCUUCCACAGGGCUC… 980 nt 0.5643
NM_001378950.1 NCBI
AUCAGAGACACUGCCCAGCCCAAGUGUCGCCGCCGCUUCCACAGGGCUC… 958 nt 0.5094
NM_001741.3 NCBI
AUCAGAGACACUGCCCAGCCCAAGUGUCGCCGCCGCUUCCACAGGGCUC… 840 nt 0.5524
Summary

This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]

Forensic Context

A study in humans using transcriptomic data and qPCR validation demonstrated that the CALCA is a commonly used clinical biomarker for sepsis with rapid and sensitive diagnostic performance for bacterial infection [Leng et al. DOI:10.1186/s12865-025-00702-x].