Basic Information

Symbol
CARTPT
RNA class
mRNA
Alias
CART Prepropeptide CART Cocaine- And Amphetamine-Regulated Transcript Protein Cocaine And Amphetamine Regulated Transcript
Location (GRCh38)
5:71719275-71721048
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Drug abuse diagnoses Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004291.4
Sequence length
800.0 nt
GC content
0.4662

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-221.70 kcal/mol
Thermodynamic ensemble
Free energy: -239.99 kcal/mol
Frequency: 0.0000
Diversity: 253.48
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
....(((.((((((.......((.((((((..((((..(((....)))((((((((((((.((((.((................)).))))....)))))))))))))))).))))))...))(((.......(((((((((((((((((((((.(.((.(((........)))))).)))....(((((((((((.((((((......)))))).((((((..(((((.(((.((...(((.((((...((((....((((((((((((((.((((((.((((((((.(((((((((((..((((.((((...((((((.........((((((((((((.((...(((((.....)))).)....)).))))).))......))))))))))))))).)))).....(((((((((((((((((.((..(((.....))))).)))..........(((((((...))))))))))))))..))))))).))))))))))))))))................(((((.((......)))))))....))).)).))))..))))))).))))))).((((((((....))))))))((((...))))...)))).)))).)))...)).))).)))))....)))))).........)))))))).))).)))))))))......(((((......)))))....))))))))).........)))........((((.....)))).......)))))).)))...((..((((........))))..)).......
Thermodynamic Ensemble Prediction
.((((.(((((((((,.{({,((.((((((..((((..(((....)))((((((((((((.((((.((.,,....,........)).))))....)))))))))))))))).)))))){,,|...{{{{{{{((((((.((((((.,(((((..{....},,))))).....(((((..{|.({(.(((......}))}))|,,..))))).))))))...)))}}},,.,{,.,{,|.,{{.((((((...,{.....,.(((.((((((.{((((((.{...(((.((((((((((((,,((((((((,.{{.{,..,.}.,,.)))))......))))}}...}))))))))))).).))))))}.....))))))))}..,.}})))))).)).,.,},,.....,{(((((((((((({{{.{,..(((.....))))|.})}.....,,...{((((({...,}})}}})))))))..)))))))})))),,,,,}|}}}}|,,....,,,,...,.,((((,,({......})))))}....,{{{{(({.,...,)))))),}}}}},}.|{{{{{{{....))))))))}}})))))..)))))))))...(((((.,....},))))},.{{{{(({{,,.....{((({.{(((((((({.|,{{{{{{{.{{,...|||,.}}}.}))),,.{|{{|.,,||||{{,......,||........||{{....,))))}}...,}})}.}))))))))}}..})))},,}}}}})),}...........

Transcripts

ID Sequence Length GC content
NM_004291.4 NCBI
AACGACGAGUUUCAGAACGAUGGAGAGCUCCCGCGUGAGGCUGCUGCCC… 800 nt 0.4662
Summary

This gene encodes a preproprotein that is proteolytically processed to generate multiple biologically active peptides. These peptides play a role in appetite, energy balance, maintenance of body weight, reward and addiction, and the stress response. Expression of a similar gene transcript in rodents is upregulated following administration of cocaine and amphetamine. Mutations in this gene are associated with susceptibility to obesity in humans. [provided by RefSeq, Feb 2016]

Forensic Context

A study in rats demonstrated that the CARTPT mRNA expression in the hypothalamus and frontal cortex showed no significant change in a fatal hypothermia group compared to controls [Umehara et al. DOI:10.1016/J.Legalmed.2011.01.005]. In mice selectively bred for methamphetamine consumption risk, the CARTPT was mentioned as a gene upregulated in a rat model of compulsive methamphetamine taking but was not experimentally studied in that investigation [Hitzemann et al. DOI:10.3390/brainsci9070155]. A study in rats and mice demonstrated that the CARTPT mRNA is increased in the hippocampus following experimental traumatic brain injury [Dash et al. DOI:10.23/B:NERE.0000023614.30084.eb].