Basic Information

Symbol
CASP4
RNA class
mRNA
Alias
Caspase 4 ICH-2 ICE(Rel)II TX Caspase 4, Apoptosis-Related Cysteine Peptidase Caspase 4, Apoptosis-Related Cysteine Protease ICE And Ced-3 Homolog 2 ICE(Rel)-II Protease TX Caspase-4 CASP-4 Mih1 Apoptotic Cysteine Protease Mih1/TX Protease ICH-2 EC 3.4.22.57 ICEREL-II EC 3.4.22 Mih1/TX ICH2
Location (GRCh38)
11:104942866-104969366
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001225.4
Sequence length
1296.0 nt
GC content
0.4552

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-348.20 kcal/mol
Thermodynamic ensemble
Free energy: -374.96 kcal/mol
Frequency: 0.0000
Diversity: 284.53
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..((((.((.((((((....((((((.....((((((...))))))..)))))).))))).).)).))))......(((((.(((..(((.(((.(((((((.((....)).))))..)).).))).)))..))))))))..(((..((((((((....(((((((((((......(((((((((............(((((.......)))))((((((((((..((((((...((((((((..((........))...)))))))).....((((((((......................))))))))............(((((((((.(((.((((...))))........((((((...(((((((((((.((((.(((...))).)))).............(((.((....)).))).(((......)))((((..((...((....)).))..))))............))))))))))).))))))..((((((((.(((((..(.(((((((.((((((.......((.((..(((..((((((((((.((.((((((((..........)))))...(((.(((...((...((((.(((((((.((.((((........(((((........))))).(((((((((..((((.......((((((.((((.(((.((.....)).)))....))))...))))))....)))))))))))))............((((...))))...........)))).)))))))))))))....))..)))..)))))).)).))))))))))...)))..))...))........))))))))))))).).)))))...)))))))).((((..((((.((((.(((((..............)))))))))....)))).))))(((((((.(((.(((((((....((((((((((((((........))))..))))))).)))..))))))).))).)))))))...................((((.((((((((((.((((....)))).)))....)))))))))))))).))))..((....))..))))).((((............))))..))))))....))).)))))))..))))))))).))))))..((((...(((....(((...)))....))).))))..((((((.(......).))))))..))))).))))))))..)))............(((((.(((((.......))))))))))....
Thermodynamic Ensemble Prediction
..{((,,((.,{,((((((((((,({.....{({{((...|}}}}}.,|.||||.,..||,..}}..}}......}}},|}}|.|})))))))}..||||||....,...{{,{{{{{||,|,|||,||,,||}}||||}..(((..((((((({..{(({(((((((((......(((((((((............(((((.......)))))((((((((((.,((((((...((((((((..,{.{{......),..)))))))).....((((((({.....{................}}}}}}||,,..{{(,....,||||||{(,{{{.{(((...)}||.,...,..((((((...(((((((((((.((((.(({...})).))))....{{{,..{{.((({((,...,,.{{|.(((......))).|||..,,...((....)).})}}))),.}}...}}},..))))))))))).))))))..((((((((.(((((..{.(((((((.((((((...{...((.((.,(((..((((((((((.,,.{(({{{{(,,,,......})))},},(((.(((.,.((...((((.((((((((((.((((........(((((........))))).(((((((({,,((((..,..,.(((((({(((({({(.((,...})).))),..,))})})))}))},....))))))))))))).....,{,....{(({...}))}..,,.......)))).)))))))))))))....)}..)))..)))},,.,,.)))))))))).,.})),,))...))...,....))))))))))))).}.)))))...)))))))).{(({,,((((.{(((.{{{{{,........,,,,.}}}}||||}....,}}}.}}}}(((((((.(((.(((((((....((((((((((((((........))))..))))))).)))..))))))).))).))))))).................,(((((.((((((((((,((((....)))).,}))},,))))))))))))},.))))..,}..,,|...}}}),.((((............))))..))))))..,.))).)))))))..))))))))).))))))})}|(((..{{{....{{{..,))}....},},},,),.((((((.{......}.))))))..}}}}}.})))))))..))).........,,,|{{||.,||||,,...,})))}))}},,....

Transcripts

ID Sequence Length GC content
NM_001225.4 NCBI
ACUCUGAGGCUCUUUCCAACGCUGUAAAAAAGGACAGAGGCUGUUCCCU… 1296 nt 0.4552
NM_033306.3 NCBI
ACUCUGAGGCUCUUUCCAACGCUGUAAAAAAGGACAGAGGCUGUUCCCU… 1395 nt 0.4509
Summary

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human cadavers demonstrated that mRNA in liver tissue remains stable for postmortem gene expression analysis up to 48 hours, and PCR array analysis of the apoptotic thanatotranscriptome showed the CASP4 was significantly up-regulated by 4.3047-fold in decaying tissues compared to a 6-hour control, indicating its role as a pro-apoptotic caspase activated during postmortem cellular processes [Javan et al. DOI:10.1007/S12024-015-9704-6].