Basic Information

Symbol
CASP5
RNA class
mRNA
Alias
Caspase 5 ICE(Rel)III Caspase 5, Apoptosis-Related Cysteine Peptidase Caspase 5, Apoptosis-Related Cysteine Protease Protease ICH-3 Protease TY Caspase-5 ICE(Rel)-III EC 3.4.22.58 TY Protease ICEREL-III EC 3.4.22 CASP-5 ICH-3 ICH3
Location (GRCh38)
11:104992636-105023168
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004347.5
Sequence length
1446.0 nt
GC content
0.4357

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-366.30 kcal/mol
Thermodynamic ensemble
Free energy: -395.45 kcal/mol
Frequency: 0.0000
Diversity: 406.09
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((.(.......((((((((..(...(((..(((((......((((((..........((((((((((((((((((.((((.........((((((((.((.(...(((((...(((((.....(((.(((...(((((((.(((((..(((...((((((.(((((.............((((((.((.......)))).))))........................((((.......)))).......)))))...)))))))))))))).)))))))...))).))).....))))))))))).)).))))))))....................((((..((.....((((((...(((((((((((((((((((.((.(((((.....))))).))..........)))))))........(((......)))....)))))))..((((((.......((((((..((..(((........)))..))..))))))........))))))....((((.((((((((.....((((.(((((((((.............((((((..(((............(((((((....((....))....))))).))..((((........((((..((((((..(((((.((..((((.......(((((....((((.......(((((.......)))))((((.....((((((((..(((....((((....((((((((((((.....((((((((((((...(((((.((((...((.......)).)))).))))).)))))))))))))))))))).)))).((((...))))...((((......))))...............(((.(((.(((.....).)).)))..))))))).)))..))))))))...))))..((((...))))...))))..))))).....))))..))))))))))))).)))).((((((.(((((...)))))..))))))))))...)))..))))))....))))))).)).).)))..((.((((((...)))))).)).....)))))))).)))).(((...(((..(((.(((....((((........))))...))).)))..))).))))))))...))))))....))...)))).)))))))).))))...)))))))).))))))))....((((...((((((((.(((......))).))))))))))))..(((....)))(((.((((..........((((....))))..(((((........)))))....)))).)))................))))).))).).))))))))........).)))))........(((.....)))((((((..(((((.............)))))..)))))).
Thermodynamic Ensemble Prediction
.(((((.{.......((((((((..(...(((..(((((......(((((,.........{((((((((((((((((({.{({{,,,,,{,{{((({(({,.{{||,,,||||,.|,|{(((.....,||},{{...,,{,,{,.{{{(({((((........|.})))}.}|,..|,..,..,||{||.{{....,,.}}}}.||||.......,,}..,,,,............{{{,,{{||||{{{...,|||||{..|||,||||||||||.|||||||{{,|,|{|||.....}}}||||||||.,|.}|},,}}},,,,............,,,,.||,,.||},,},||||||,,.(({{{((((((((((,({,,{{.(((((.....))))).}}.,,......{||||..,.,,}}}..,{,,.....}}}},,.,}))))},,{(((((.......((((((..,(,.(((.,,.....))),,}}..))))))........)))))|{{{{(((({(,((((,({,...,}}.}}}|,,{{((,..........,{(((((({.{{,{{{.........,,{{{{|},..({....}},}}}}))))}))}}}|||,..}}}}}||||},((((((..(((({,((..(((({(.....(((((....((((.......(((((.......)))))((((.....((((((((..(({.....,,{....((((((((((((.....((((((((((((...(((((.((((...({.,....,)}.)))).))))).)))))))))))))))))))).)))).((((...))))...((((......))))...............((({((({{{......}.)).)))},,,}}}}}.)))..))))))))...)))}..((((...))))...))))..)))))....)))))..)))))))))))))...,)}||||||}||||,..})))})..,,)))))))),,))))}.,,,,}},,,,|,|||,,.,}}),)}..{(({(((((({{{||||,|{,|{|{|,|,,|||}|{{|||.(.....,||,,|||.||||||.((((........))))..|||||}},{{,|....)))}))},,))))))..,}))}}.},,,.,}}))))))})),,..}))))))).))))))))....{(((,..{(((((((.(((......))).)))))))))))}..(((....))),,,.{{{,..........{{{|,,..}}}}..{((((........))))).{{{|},..,|.............}}}}))))).))),,.))))))))........,.)))))...,,,,,(({,.{{,.,.{{||{{..||{||,}|}.........,}}}}..})))}}.

Transcripts

ID Sequence Length GC content
NM_001136109.3 NCBI
AGUGCUGUACAAAGAGACAGAGGCUGUUAGCUAUGGCUGAAGACAACCA… 1272 nt 0.4418
NM_001136110.3 NCBI
AGUGCUGUACAAAGAGACAGAGGCUGUUAGCUAUGGCUGCUCUUCUGCA… 1020 nt 0.4618
NM_001136112.3 NCBI
AGUGCUGUACAAAGAGACAGAGGCUGUUAGCUAUGGCUGCUGUGCCCAG… 1485 nt 0.4350
NM_004347.5 NCBI
AGUGCUGUACAAAGAGACAGAGGCUGUUAGCUAUGGCUGAAGACAGUGG… 1446 nt 0.4357
Summary

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]

Forensic Context

A study in human prostate tissues demonstrated that the CASP5, a pro-apoptotic gene, was not overly expressed at lower postmortem intervals but showed increased expression at longer intervals of 96 and 120 hours, indicating its potential for time of death estimation [Tolbert et al. DOI:10.1016/j.gene.2018.06.090].