Basic Information

Symbol
CCL25
RNA class
mRNA
Alias
C-C Motif Chemokine Ligand 25 TECK SCYA25 Ckb15 Small Inducible Cytokine Subfamily A (Cys-Cys), Member 25 Chemokine (C-C Motif) Ligand 25 Small-Inducible Cytokine A25 Thymus Expressed Chemokine C-C Motif Chemokine 25 Chemokine TECK Ck Beta-15 TECKvar Thymus-Expressed Chemokine
Location (GRCh38)
19:8052293-8062665
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005624.4
Sequence length
991.0 nt
GC content
0.5732

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-363.10 kcal/mol
Thermodynamic ensemble
Free energy: -380.07 kcal/mol
Frequency: 0.0000
Diversity: 200.55
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((((.((((((..(((((.....((((((((((((.(((.((((..(((((.(((((((.(((.((...........((((((((.(((((((((..((..(((((.((((((.((.((...)).)).))..))))..)))))))..))))))))).))))))))))))).)))))))......)).)))...).)))))).))))))(((((((.(.........))))))))(((((....)))))..(((((.....(((..(((((((((((((((((((((...(((((((((((...........(((((...((((.(((((.((((.(((((...(((.......))).((((((((((((......)))).((((.((((((((......)))))...)))))))............((((..(((.(((((..((((.(((.......)))))))...((((...)))).....((((.((((....(((((......(((((.........((((........)))))))))....)))))....)))).)))).(((((((.((((((.(((.....))).))))))))))))).........((((......))))(((...((((..((.(((....))).))..))))...))).............)))))...)).)..)))).....))))))))))))))))))))))...))))(((((..((((((.(((......)))..))))...))..))))).....)))))...)))))......))))))...))))))))))).((((..............))))))))))))))..)))....)))))..))))))...)))))..))))))))))(((...(((..((((......))))...))).)))(((((((((.(((...................)))...)))))))))...........
Thermodynamic Ensemble Prediction
.((((.((((((..(((((.....((((((((((((.(((.((({..(((((.(((((((.(((.((({..,......|,{(((((.(((((((((..((..(((((.(((((,.({.((...)).)).}}},})))..)))))))..))))))))).))))))))).))).)))))))......)).)))...}.)))))).))))))(((((((.{.........)))))))),((((....))))}..(((((...,.(((..(((((((((((((((((((((...(((((((((((...........(((((...((((.((((,,((((.(((((..,(({.......))).((((((((((((......)))}.((((.((((((((......)))))...))))))}.........,..((((..(((.(((((..((({.(((.......})}})))...((({...}))}.,...{(({.((((....(((((......{((((..,......((((........)))}))))}....))))).,..)))).)))).(((((((.((((((.(((.....))).))))))))))))).........,(((......}}}|(((...((((..{(,{(,....}}),,,..))))...))))............)))))...)).)..))))....}))))))))))))))))))))))...))))(((((..(({((,.(((......)))..))),...))..))))).,,..)))))...))))),.....})))))...))))))))))),(((,.,......,...,}))))))))))))))..))).,..)))))..))))))...)))))..)))))))))).....(((({..,{(,{,{..,..,,..}}..,|{(({(({(((.{{{...................}}}..}))})))))),,.}))))...

Transcripts

ID Sequence Length GC content
NM_001201359.2 NCBI
GCAGAUGGGACAGCUUGGCCUACAGCCCGGCGGGCAUCAGCUCCCUUGA… 988 nt 0.5729
NM_001394634.1 NCBI
GUGACAUGCUAAGUUACCUAACCAUGAUGGGACAGCUUGGCCUACAGCC… 1013 nt 0.5686
NM_001394635.1 NCBI
GUGACAUGCUAAGUUACCUAACCAUGGUGUGGAAGGAGAGGGAAAUGGA… 1092 nt 0.5714
NM_001394636.1 NCBI
GUGACAUGCUAAGUUACCUAACCAUGGUGUGGAAGGAGAGGGAAAUGGA… 1157 nt 0.5730
NM_001394637.1 NCBI
GUGACAUGCUAAGUUACCUAACCAUGGUGUGGAAGGAGAGGGAAAUGGA… 1167 nt 0.5733
NM_001394638.1 NCBI
GUGACAUGCUAAGUUACCUAACCAUGGUGUGGAAGGAGAGGGAAAUGGA… 1164 nt 0.5730
NM_005624.4 NCBI
GCAGAUGGGACAGCUUGGCCUACAGCCCGGCGGGCAUCAGCUCCCUUGA… 991 nt 0.5732
Summary

This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Forensic Context

A study in mice demonstrated that during gingival wound healing, the chemokine CCL25 (TECK) gene expression was elevated at 24 hours post-wounding and then down-regulated by 72 hours, suggesting a self-limiting recruitment of lymphocytes and dendritic cells [McGrory et al. DOI:10.1016/j.bbrc.2004.09.056].