Basic Information

Symbol
CCL5
RNA class
mRNA
Alias
C-C Motif Chemokine Ligand 5 TCP228 SIS-Delta D17S136E RANTES SCYA5 SISd Regulated Upon Activation, Normally T-Expressed, And Presumably Secreted Small Inducible Cytokine Subfamily A (Cys-Cys), Member 5 Eosinophil Chemotactic Cytokine Chemokine (C-C Motif) Ligand 5 T-Cell Specific Protein P288 Beta-Chemokine RANTES C-C Motif Chemokine 5 MGC17164 EoCP Small Inducible Cytokine A5 (RANTES) T-Cell Specific RANTES Protein T-Cell-Specific Protein RANTES T Cell-Specific Protein P228 Small-Inducible Cytokine A5
Location (GRCh38)
17:35871491-35880793
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Mechanical injury analysis Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002985.3
Sequence length
1217.0 nt
GC content
0.5399

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-419.00 kcal/mol
Thermodynamic ensemble
Free energy: -440.52 kcal/mol
Frequency: 0.0000
Diversity: 382.91
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..((((((((....((..((((((.((((((((....((((.......))))....)).)))))).)).((((((....))))))........)))).))..))))))))(((((((.((.(((((((.....((....))((((.((((((((((((.((............((.....))...(.((((...(((((((((....((((....))))...(((((((((((((....((.((((((............(((((...))).)).......)))))).))..))))))..)))))))..((.(((....))).))((((((((..((((((....(((.(.....................).))).....)))))).))))))))(((((((.....)))).))).............))))))))).)))).)...........)).)))))))).........((((((..((((((((((.((((.....)))))))....))))).))..))))))....))))))))((((......))))(((.(((((..(((((((((((......((((......)))).......................))))))).))))..))))).)))(((((....)))))..))))))).)).))))))).((((.((((....((((((((((((((((((((.((((....)).))))))))(((((..(((((...((((((((((((...)))))................................(((((((((((((....)))))))))........))))...((((((((.((((((.....))))))..(((((((...(((((..((.((((.((.........)))))).))))))).)))))))......((((.......))))................))))))))....(((((((.((((((((((..(((((..(.((((....)))).).))))).)))))))....)))))))))).((((((...)))))))))))))..)))))..)).))).....(((((....)))))(((((.(.((.....)).).))))))))).)))))).))))......)))).(((((((..(((......(((....))).....)))...)))))))........))))...
Thermodynamic Ensemble Prediction
..{(((((((....{(..((({((,((((((((....((((.......))))....)),}))))).)),((((((....))))))........}))}.}}}.)))))))}{((((((.{{.(((((((......,{,{((,{{{(.({{{((,((((({(({((....,((((((((((.({({.(.(({(...({{{((((({{({((((....)))).}}|||||||,{{{{{,,..({.((((({.,.....,,,},,|.||...}})})}},.,,,,||}}}}.}}..)))))).,)||||}}..,,,|||..,{|||,||(((((((((,{(((((....(({,..{,{,...........,,...)))),.,...)))))))))))))))|((((((.....)}}}.,,,.......|{,,,,|}}}||||}.}|}}...,...,,{{{,{..||||||.}.........{{{{{{..{{||||{,,|,||||,....})))}}}..,,|||}}.}}.,)))))),,,,))))))))}{{{,..,,.(((((((.(((...,||,..))))))).....|{|{......)))),,,....................))})))))))),.)))))),||}|{(((....))})}..))))))).))})))),))..|||.|||,..,,|||((((((((,,(((((((.((((....)).))))))))}||||.,|||{{,{.,{{{{||(((((...)))))................................(((((((((((((....)))))))))........)))}...|||||||{.,,||||},...|||||{{.{{{{(((.{{((((({{(({((((.((,,.,,.,{,}}}}}}.))))))),)}}}}||{{|..{(({,.,},..}))))................,}||||||,..,(,{{(((,(({{({(((({{(((((,.{.((((.,..,}}),}.))))),)))}}},{{{{||||||}},|({,,{||...))))))))))})}},))}))..})},),,,,,.{((((....))))}||{{|}|}||}..,,))}).}}},,.}))))))))).)))}......}},}.{((((((,.(((.{{.,.(((....))),.}}.))).,,)))))))....},..,,,,...

Transcripts

ID Sequence Length GC content
NM_001278736.2 NCBI
CCUGCAGAGGAUCAAGACAGCACGUGGACCUCGCACAGCCUCUCCCACA… 1299 nt 0.5404
NM_002985.3 NCBI
CCUGCAGAGGAUCAAGACAGCACGUGGACCUCGCACAGCCUCUCCCACA… 1217 nt 0.5399
Summary

This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokine s form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine , a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligand s for the chemokine receptor chemokine ( C-C motif ) receptor 5 (CCR 5 ), and it suppresses in vitro replication of the R 5 strains of HIV-1, which use CCR 5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

Forensic Context

A study in humans demonstrated that the CCL5 is a core immune-related differentially expressed gene with diagnostic potential in both severe burns and blunt trauma, showing consistent expression trends in validation datasets [Chen et al. DOI: 10.3389/fgene.2022.1038222]. Separate research in humans identified the CCL5 as having high diagnostic value for post-myocardial infarction heart failure, with quantitative PCR validation confirming its expression increased sharply in patient blood samples [Sun et al. DOI: 10.3389/fimmu.2023.1163350]. A study in mice demonstrated that the CCL5 is a key chemokine upregulated during the inflammatory response to acute liver injury, where its mRNA expression was significantly elevated in liver tissue following LPS/D-GalN or alcohol induction and was effectively reduced by acetylcorynoline pretreatment, which inhibits the TLR4/JNK/NF-κB pathway [Fu et al. DOI:10.1016/J.Intimp.2024.113550].