Basic Information

Symbol
CCNE1
RNA class
mRNA
Alias
Cyclin E1 CCNE G1/S-Specific Cyclin-E1 Cyclin Es Cyclin Et PCCNE1
Location (GRCh38)
19:29811471-29824313
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001238.4
Sequence length
1954.0 nt
GC content
0.5174

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-688.00 kcal/mol
Thermodynamic ensemble
Free energy: -723.72 kcal/mol
Frequency: 0.0000
Diversity: 588.50
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...(((((((((((.(((((...((((((((..(((((.(........)))).))..))))))))...))))))))))..(((((((((.((.((.((.((....)).)).)).)).))..)))))))..(((((.(((.(((((((((.((....((((((((((.(((((((((((((......((((((((((((..((((((((((.((.((.....((.(..(.((.....)).)..).))(((((((((.(((((((((.(((((((((((((..((((....)).))(((((((((((.(((((((((.........(((....((((((((.(((((.(((..(((((((((((..(((...(((.......((((.....))))...))).)))..))....)))))).))).........(((.(((..(((....)))....))).)))...((((((((((.........)))).)))))))))))))))))))..)))....))).............)))))))...)).)))........))))))))...(((((((((.......)))))))))......))))))))(((........)))((.((((((....)))))).))..)))))...((((((((......))))))))(((.((.....(((((((((.....((((((((.(((.....)))...)).))))))..(((((((((....)))))))))....(((.(((((((..(((((((.(((((((.((((((((((......)))))..)))))(((......)))((((((((((.....(((.....(((((.((((((((((......))))))........((((.((((....).))).))))((((....)))).)))).))))))))...))).))))))).)))))))....))))))).....))))))).))).))))).))))))))).((((.(((......))))))).))))))..))).))))))))).)).)).))).)).)))))..)))))))..)))))....)))))))))))))(((((((.(((.........))).)))))))..))))..)))))).)).)))))).)))......(((((((.((((((((....)))))))).)))))))....((((((.(((((((((.........((((((((..(((...)))..))))).))).....................(((((((.(((.((((((.(........).)))))).....))).)))))))..........))))))))).))))))..))).))))).....((((......))))......(((((((((((.((((....)))).))......((((((.........((((.(((.(((((((((((((.(((..(......)..))).).)))..))))))))).)))))))..(((....)))..(((((((.....)))))))..((((((....))))))))))))((((((...(((((((((((((......)))))))).(((((((((..........((((((((((.....(((.(((((((.....(((((((......)).)))))...))).))))))))))))))))).(((...)))........))))))))).(.(((((((((((((((....)))))))))))..)))).).......((((((((......))))))))((.((((((.((((..((.....))...)))).)))))).))((((((....)))))).....(((((.((....)).)))))....)))))))))))..)))))))))....))))))...................((((((((....)))))))).....
Thermodynamic Ensemble Prediction
.{{(((((((((((.(((((...((((((((..(({((.,........,))).))..))))))))...))))))))))..{((((((((.((.((.((.((....)}.)).)).)).)}..))))))}..(({(({((({,(((((,((,{({,.{((,((((((...||||||,((,(({{{.{{.,,,,|||||,|}}|(((((((((((,((..{((.(((,(((.,..{(,(((((({,((.((((((..{((,|{((((((((((.(.(((((({.((((....}}.}),|}}}|}}.}.}},,{{{{,{,......|||((....(({(((((.(((((.(((,.{{(((((((.,.(({....(((,,.....((((.....))))...,,}}),}},))).,.))))))}|}}.........{((.(({..(((....)))....))}.)))...{(((((((((.........)))).)))))))))))))))))))..}))..||)}){{{{{{{{{.{{{||||,||..,{{.(((....{{,{..,,{{,,.,,(((((((({.......|||||||||,.((({{{(((..,(((........))){(.((((((....)))))).)}...}))))})|(((((((......)))))))|{{....}))},,.||||,,|}},|,||||||||.||{,,...}))},.,,.}}}},...(((((((((....)))))))))...}},}}}||||,|}}|||}}|..{(((({|.(((({(((((......)))))..}))))||,...,,})))|||,||||||,,}}}|||,,}}}|||||||||.{{(((|,.....)))))}........{{{{.{|||,,,,),))),)))}{|||,,,,}}}}.}})),)))))}||..,|||,,,|||||{|||,|||,,||,..,|}...,,}}}},,}|{|{.{{{|{{{.|,,,,.{(((((..(((.,{...,,,.}}.}}}..)))))).,{{||||{{{..|.||.|{{{.{{|||||{{..,|||{..||||,...,)))||,,}})),{(((((((.(((.........))).)))))))},))),})))))))}))}),,)),,)))}}}}}}|((((((.((((((((....)))))))).))))))}....((((((.(((((((((....,{{,,{{{{||||,.(((,,,,}}..}}}}),)))............,.,......(((((((,({{.(((((({(.......}).))))))..,,,)}},))))))),.........))))))))).))))))..|||{|,,,,....))})|......))))}..}.,))},.}}}))))))))).}}},,)))).}}.)}}}.)}))})}.,...,,,|.,,|}}.}}},|||||}}}.|}}}}}}}...)}}))}})},)))))))))))),.,{(({((((((((.,((((..(((((((,...,)))))))...))))......)))))))).)))},,,..{((((({((((((((......)))))))).,{{(((({,..........(((((((((({....,({{(((((((.....(((((((......)).)))))...))),,)))))))))))))))).(((...)))....,,,,,},||||}|.|.((({(((((((((((....)))))))))))..)))).}})))}),|||{{||||,..,.}|})))))((.((((((.((((..((,...,))...)))).)))))).))((((((....)))))).,}}}||,{{,,({{..|{{{{|,|,{,,,},,.))),)}.}}))},,}},.,},)))))).....,........,,...,|{|||||....}))))))}.,,..

Transcripts

ID Sequence Length GC content
NM_001238.4 NCBI
AGGAGCAGCCGGCGCGGCCGCCAGCGCGGUGUAGGGGGCAGGCGCGGAU… 1954 nt 0.5174
NM_001322259.2 NCBI
AGGAGCAGCCGGCGCGGCCGCCAGCGCGGUGUAGGGGGCAGGCGCGGAU… 1819 nt 0.5228
NM_001322261.2 NCBI
AGGAGCAGCCGGCGCGGCCGCCAGCGCGGUGUAGGGGGCAGGCGCGGAU… 1807 nt 0.5296
NM_001322262.2 NCBI
AGGAGCAGCCGGCGCGGCCGCCAGCGCGGUGUAGGGGGCAGGCGCGGAU… 1907 nt 0.5118
Summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016] CIViC Summary for CCNE1 Gene Cyclin E, while currenly not as widely implicated as its cyclin D counterparts, has been implicated in various carcinomas, including breast, gastric, stomach and colorectal. High levels of cyclin E, either by gene amplification or overexpression, have been shown to lead to poorer prognosis in gastic carcinoma, and these measurements are correlated with later stage disease. In lung cancer, neoplastic cells with higher levels of the cyclin E/CDK2 complex are more radiosensitive than their more lowly expressed counterparts.

Forensic Context

A study in mice and human hepatic cells demonstrated that the CCNE1 is among the genes whose expression is decreased by ectopic expression of miR-21, which is upregulated by IL-6/Stat3 signaling during alcoholic liver injury to promote cell survival by directly targeting pro-apoptotic proteins FASLG and DR5 [Francis et al. DOI:10.1074/Jbc.M114.602383].