Basic Information

Symbol
CCNH
RNA class
mRNA
Alias
Cyclin H P34 P37 MO15-Associated Protein CycH Cyclin-Dependent Kinase-Activating Kinase Complex Subunit CDK-Activating Kinase Complex Subunit CAK Complex Subunit Cyclin-H CAK
Location (GRCh38)
5:87318416-87413029
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001239.4
Sequence length
1280.0 nt
GC content
0.4227

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-326.80 kcal/mol
Thermodynamic ensemble
Free energy: -352.89 kcal/mol
Frequency: 0.0000
Diversity: 290.44
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((.((((((((((.....((((((((...((((((((..........))))))))..))))))))...))).)).))))).)))))..(((((.((((((.((((...)))).)..((((((((.........(((......)))(((.((.((((((((.(((((.....))))).).((.((((((.(((....))).))))).).))..))))...))).))))).....))))))))...(((..((((....))))..)))((((((((((...(((((((....((((((..(((.((.......)))))....))))))(((.((((....(((((..(((((((((......(((((((..(((((((((.......)))))((((.((.((((((.((......((((((...((........))((((.(((.(((((........))))).))).)))).............((((.((((((((((((((((....(((((...((((((((.(((..((((((((((...((((..............(((..(((.(((....))).))).)))..............)))).))))))...................(((((....)))))........))))...))).)))).....))))..))))).....)))))))...((((.(((((((((((..(((((((((((((....))))).....................(((....((((((...((.(((......)))))...))))))))))))).))))))))))))))).((((((...)))))))))).......((((.......))))........))))))))).))))..)).))))......)))))))).)).)))))))).)))))))(((((.((((((.(((((...))))....).)))))).)).)))))))).)))))))))..(((((((((((......((......)).......)).))))))))).....)))).)))...)))))))...))))).)))))))))).)))))((((((.....))).))).(((((((.((........(((((..(((.((....))..)))..))))).....(((((..(((((......)))))..)))))(((((((........................)))))))..................(((((.....))))).)).)))))))...
Thermodynamic Ensemble Prediction
,(((((.((((((((((,,,..{(((((((...((((((((({,....)),})))))))..)))))))),,.))).)).))))).)))))}.(((((.(((((,.((((...}))).,..((((((((.........{({......,}}{{,{{(.{{{(((({.(((({.....})))).).((.((((((.(((....))).))))).).))..))))...}}}.,})}}.....)))))))).,,(((,{,,,|}}}}}.....||{({((((((({...(((((((....,{((((.,(({.,,.......,}))}....))))||(((.((((,,,.(((((..(((((((((......(((((((..((((((((,.{{{.,,}||,{((((.{{.((((((,,,......{{{{||..,||..,,,,,,..((((.{((.(((((........))))).))}.))))....}}.}}}}..{(((.((((((((((((((((,{{.(((((...((((((((.{((.,{{{(((((({,,,{(((....,,...{{...(((..(((.((,....})).))).)))...,}......,,.}))).))))))}....,,.....,......{((((....))))}.........,)}...}}}.)))).....))))..))))),}}..})))))}...{(((.(((((((((((..((((((({(((((....))))).....................(((....((((((...(,{(((......)))))...))))))))))))).))))))))))))))).((((((...)))))))}}}.....{.{(((.......))))}.,.,..,))))))))).))))..}}.)))),.,,.,}}},))),.)),),,.)))).)))))))(((((.((((((.(((((...)))),...}.)))))).}).)))))))).)))))))))..|(((((((({{......{(......)).,.....}}.))))))))).....)))).))),..))))))),,,)))),,))))}))))).))))|((((((.....))),,)),{((((((.((,,......(((((..(((.({....))..)))..))))).....{{(((..{((((......})))}..}}|||((((({{.,.,,...................)))))))......,}},|||...,,|||,|}}.,,,}}}}.)).))))))}...

Transcripts

ID Sequence Length GC content
NM_001199189.2 NCBI
AGCGCGCCAGCGCCGGCUAGCCGGACGCCCUAGGCUUCCGCGAGAUCUU… 1523 nt 0.4412
NM_001239.4 NCBI
AGCGCGCCAGCGCCGGCUAGCCGGACGCCCUAGGCUUCCGCGAGAUCUU… 1280 nt 0.4227
NM_001363539.2 NCBI
AGCGCGCCAGCGCCGGCUAGCCGGACGCCCUAGGCUUCCGCGAGAUCUU… 4378 nt 0.3840
NM_001364075.2 NCBI
AGCGCGCCAGCGCCGGCUAGCCGGACGCCCUAGGCUUCCGCGAGAUCUU… 2394 nt 0.4098
NM_001364076.2 NCBI
AGCGCGCCAGCGCCGGCUAGCCGGACGCCCUAGGCUUCCGCGAGAUCUU… 4621 nt 0.3921
Summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Nov 2010]

Forensic Context

A study in human skin tissue demonstrated that burn injury significantly alters the T cell landscape, with a lower proportion of CD8+ T cells compared to non-burn skin [Labuz et al. DOI:10.7554/eLife.82626]. These burn-infiltrating CD8+ T cells exhibited a pro-inflammatory, circulating phenotype characterized by significantly higher production of IFN-γ and TNF-α upon stimulation, lower expression of the tissue residency marker CD69, and higher transcriptional expression of homing receptors CCR7, S1PR1, and SELL compared to their counterparts in non-burn tissue.