This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. The SRCR family is defined by a 100-110 amino acid SRCR domain, which may mediate protein-protein interaction and ligand binding. The encoded protein contains twelve SRCR domains, a transmembrane region and a cytoplasmic domain. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Forensic Context
A study in humans using single-nucleus RNA sequencing of cardiac tissue from ischemic cardiomyopathy patients demonstrated that the CD163L1 is upregulated in macrophages and is associated with tissue-resident anti-inflammatory macrophages [Simonson et al. DOI:10.1016/j.celrep.2023.112086]. Another study in human neonates with hypoxic-ischemic encephalopathy found that the CD163L1 was a top differentially expressed gene upregulated in whole blood and associated with adverse outcome and HIF-1α signaling in a high-income country cohort [Montaldo et al. DOI:10.1001/jamanetworkopen.2023.54433].