Basic Information

Symbol
CD3D
RNA class
mRNA
Alias
CD3 Delta Subunit Of T-Cell Receptor Complex T-Cell Surface Glycoprotein CD3 Delta Chain CD3-DELTA CD3DELTA T3D CD3d Antigen, Delta Polypeptide (TiT3 Complex) CD3d Molecule, Delta (CD3-TCR Complex) T-Cell Receptor T3 Delta Chain CD3 Antigen, Delta Subunit OKT3, Delta Chain CD3d Molecule CD3d Antigen CD3 Delta IMD19
Location (GRCh38)
11:118334537-118342705
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000732.6
Sequence length
701.0 nt
GC content
0.5093

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-223.50 kcal/mol
Thermodynamic ensemble
Free energy: -236.97 kcal/mol
Frequency: 0.0000
Diversity: 146.59
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
......(((.....(((((.((..((((((((((((..((((.((((...(((((.((((....))))..)))))..)))).))))....((..(((((.(((((.......)))))))))).)).(((((.(((((...((((.((((((((.((((..(((((((.(.(((....)))).)))))))..((((((...((((.........(((((.((((((.((((((((((.(((((....))))).))))..............(((..((((((.......))))))..)))......((((((..((........))..))))))..............))))))(.(((.((((......)))).))))......)))))).)))))..(((((((...)))))))(((((.......)))))))))...)))))))))))))))...)))((((((.((((.....)).)).))))))((..(((((((((((((((..(((.......(((....)))..........)))...)))))))...((((((.....))).))))).)))))).)).((((((..(((((.(((((...........))))).)))))..)))))))))).))))).))))).)))).)))))))).)).))))))))........................
Thermodynamic Ensemble Prediction
......(((.....(((((.((..((((((((,(((((........)))))((((((.(((((..(((((...,((.{{(({..{({.(((((,(((((.(((((.......))))))))))}))..)).})}(((((((..((((((((..{((((((((((((((.{.(((....))),.)))))))....,{{{{{(((((..(((.......)))))))}...,,.(((((..(((((....)))))})))).,}}}},....({.(((((((((..,..,.,,((((.(.....).)))}{(((((,.{(,{......)),.}))))),...{{........,,,.,,..(((.((((......)))).)))((((((((((((..{,{({...((({(.{{(((((((((((((.......))))))))..)))))...((((((......)))|||{{{,,((({{.{,||.,,.,}},)}}}))))),}.},))))))}})..))))),})))))).,,.}...}..)))))))))))....(((((((({{{,...,}}}{{|..,,..}}}...)))))))).....))))))}...,..))))....))))..)))))))})))).}).)))))))))))))))).)))))))).}).))))))))........................

Transcripts

ID Sequence Length GC content
NM_000732.6 NCBI
CUUUCCGGUACCUGUGAGUCAGCUAGGGGAGGGCAGCUCUCACCCAGGC… 701 nt 0.5093
NM_001040651.2 NCBI
CUUUCCGGUACCUGUGAGUCAGCUAGGGGAGGGCAGCUCUCACCCAGGC… 690 nt 0.5101
Summary

The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009]

Forensic Context

A study in elderly human hip fracture patients using single-cell RNA sequencing identified the CD3D as a T cell marker used for cell type identification and to characterize T cell clusters [Lu et al. DOI:10.1186/s12979-023-00380-6]. In a separate human study of a radiation-exposed patient, scRNA-Seq analysis showed the CD3D was highly expressed in specific NK cell subsets (NK2, NK5, NK7, NK8, NK9) and was involved in T-cell development and signal transduction, with T cell proportions notably lower in the irradiated patient compared to healthy controls [Yan et al. DOI:10.3892/etm.2025.12846]. A study in humans demonstrated that the CD3D is a gene marker highly expressed in the T cell cluster of the human corpus cavernosum, used alongside CD3E to identify this population [Zhao et al. DOI:10.1038/s41467-022-31950-9].