This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011]
Forensic Context
A study in mice demonstrated that the CD69 was significantly upregulated at 14 days post-injury in microglia isolated from brains after controlled cortical impact [Izzy et al. DOI:10.3389/fncel.2019.00307]. A study in porcine skin demonstrated that the CD69 was significantly decreased in response to both sulfur mustard and thermal burn injury at 7 days postexposure [Price et al. DOI:10.080/15569520903097754].